Evidence map›Paper›PMID 33852868›Full record

ArticleCell reports2021

UTX promotes CD8

Joseph E Mitchell, Makayla M Lund, Josh Starmer, Kai Ge, Terry Magnuson, Karl B Shpargel, Jason K Whitmire

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
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  5. Review
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  8. Review
  9. Article
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  11. Article
  12. H3K27me3 Demethylase UTX Restrains Plasma Cell Formation.Journal of immunology (Baltimore, Md. : 1950) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Joseph E MitchellDepartment of Genetics, UNC-Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA; Department of Microbiology & Immunology, UNC-Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA.
Makayla M LundDepartment of Genetics, UNC-Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA.
Josh StarmerDepartment of Genetics, UNC-Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA.
Kai GeAdipocyte Biology and Gene Regulation Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Terry MagnusonDepartment of Genetics, UNC-Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, UNC-Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA.
Karl B ShpargelDepartment of Genetics, UNC-Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA. Electronic address: karl_shpargel@med.unc.edu.
Jason K WhitmireDepartment of Genetics, UNC-Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA; Department of Microbiology & Immunology, UNC-Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, UNC-Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA. Electronic address: jwhitmir@email.unc.edu.
University of North Carolina at Chapel Hill · USNational Institutes of Health · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
Regulation of PPARgamma Expression and Adipogenesis by PTIP-Associated FactorsZIADK075003 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI GE, KAI · 2009 to 2025
$17.6M
Albino Deletion Complex and Early Mouse DevelopmentR01GM101974 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAGNUSON, TERRY R · 2012 to 2024
$5.2M
Regulation of CD8+ T cell responses to chronic virus infectionR01AI143894 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WHITMIRE, JASON KYLE · 2019 to 2023
$2.5M
Obesity associated viral pathogenesisR01AI138337 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WHITMIRE, JASON KYLE · 2018 to 2022
$1.9M
Murine Model of Human Hepatitis AR01AI131685 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LEMON, STANLEY M., WHITMIRE, JASON KYLE · 2017 to 2021
$1.9M
Genetic and mechanistic dissection of a lethal systemic virus infectionR21AI117575 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WHITMIRE, JASON KYLE · 2015 to 2016
$418k
Enhancer activation roles and mechanisms in craniofacial developmentR56DE028553 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHPARGEL, KARL BRYAN · 2020 to 2020
$369k
Epigenetic mechanism of histone modifying enzymes in craniofacial developmentR03DE027101 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHPARGEL, KARL BRYAN · 2018 to 2019
$311k
NCI NIH HHS P30 CA016086NIAID NIH HHS R01 AI131685NIAID NIH HHS R01 AI138337NIAID NIH HHS R01 AI143894NIAID NIH HHS R21 AI117575NIDCR NIH HHS R03 DE027101NIDCR NIH HHS R56 DE028553NIGMS NIH HHS R01 GM101974
6 · The paper itself

Abstract

Persistent virus infections can cause pathogenesis that is debilitating or lethal. During these infections, virus-specific T cells fail to protect due to weakened antiviral activity or failure to persist. These outcomes are governed by histone modifications, although it is unknown which enzymes contribute to T cell loss or impaired function over time. In this study, we show that T cell receptor-stimulated CD8

Indexed as

AnimalsAntigens, CDCytotoxicity, ImmunologicGene Expression ProfilingGene Expression RegulationHepatitis A Virus Cellular Receptor 2Histone DemethylasesHistonesHost-Pathogen InteractionsImmunologic MemoryLymphocyte Activation Gene 3 ProteinLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMiceMice, Inbred C57BLProgrammed Cell Death 1 ReceptorAntigens, CDHavcr2 protein, mouseHepatitis A Virus Cellular Receptor 2Histone DemethylasesHistonesLymphocyte Activation Gene 3 ProteinPdcd1 protein, mouseProgrammed Cell Death 1 ReceptorUtx protein, mouseantiviral defenseCD8(+) T cell functionepigeneticshistone demethylationLCMVpersistent infection

Identifiers

PMID33852868
PMCPMC8112613
OpenAlexW3154264608

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.