Evidence map›Paper›PMID 33852855›Full record

ArticleCell reports2021

Chronic stress physically spares but functionally impairs innate-like invariant T cells.

Patrick T Rudak, Joshua Choi, Katie M Parkins, Kelly L Summers, Dwayne N Jackson, Paula J Foster, Anton I Skaro, Ken Leslie, Vivian C McAlister, Vijay K Kuchroo and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
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  14. Effects of Psychological Stress on Multiple SclerosisCNS & neurological disorders drug targets · 2024
    Review
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  17. Role of Neurohumoral Imbalance at Post-Traumatic Stress Disorder in the Antitumor Immune Response. Experimental Study.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

Patrick T RudakDepartment of Microbiology and Immunology, Western University, London, ON N6A 5C1, Canada.
Joshua ChoiDepartment of Microbiology and Immunology, Western University, London, ON N6A 5C1, Canada.
Katie M ParkinsDepartment of Medical Biophysics, Western University, London, ON N6A 5C1, Canada; Robarts Research Institute, Western University, London, ON N6A 5B7, Canada.
Kelly L SummersDepartment of Microbiology and Immunology, Western University, London, ON N6A 5C1, Canada.
Dwayne N JacksonDepartment of Medical Biophysics, Western University, London, ON N6A 5C1, Canada.
Paula J FosterDepartment of Medical Biophysics, Western University, London, ON N6A 5C1, Canada; Robarts Research Institute, Western University, London, ON N6A 5B7, Canada.
Anton I SkaroDepartment of Surgery, Division of General Surgery, Western University, London, ON N6A 4V2, Canada.
Ken LeslieDepartment of Surgery, Division of General Surgery, Western University, London, ON N6A 4V2, Canada.
Vivian C McAlisterDepartment of Surgery, Division of General Surgery, Western University, London, ON N6A 4V2, Canada.
Vijay K KuchrooEvergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA.
Wataru InoueRobarts Research Institute, Western University, London, ON N6A 5B7, Canada; Department of Physiology and Pharmacology, Western University, London, ON N6A 5C1, Canada.
Olivier LantzLaboratoire d'Immunologie and INSERM U932, PSL University, Institut Curie, 75248 Paris Cedex 5, France.
S M Mansour HaeryfarDepartment of Microbiology and Immunology, Western University, London, ON N6A 5C1, Canada; Department of Surgery, Division of General Surgery, Western University, London, ON N6A 4V2, Canada; Department of Medicine, Division of Clinical Immunology and Allergy, Western University, London, ON N6A 5A5, Canada. Electronic address: mansour.haeryfar@schulich.uwo.ca.
Western University · CABrigham and Women's Hospital · USInserm · FR

Funding

Neuroimmune interactions regulate development of allergic inflammationR01AI139536 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI KUCHROO, VIJAY K. · 2018 to 2022
$2.9M
Neuroimmune interactions regulate development of allergic inflammationR37AI139536 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI VIJAY K. KUCHROO · 2024 to 2026
$1.8M
NIAID NIH HHS R01 AI139536NIAID NIH HHS R37 AI139536
6 · The paper itself

Abstract

The deleterious effects of psychological stress on mainstream T lymphocytes are well documented. However, how stress impacts innate-like T cells is unclear. We report that long-term stress surprisingly abrogates both T helper 1 (T

Indexed as

AnimalsCell Line, TumorChronic DiseaseCorticosteroneCytotoxicity, ImmunologicFemaleGene Expression Regulation, NeoplasticHumansImmobilizationImmunity, InnateInterleukin-10Interleukin-23InterleukinsLiver NeoplasmsLymphomaMaleCorticosteroneIL10 protein, mouseIl27 protein, mouseInterleukin-10Interleukin-23InterleukinsOxidopaminecancercytotoxicityglucocorticoidshabituationimmunosuppressioniNKT cellsinnate immunityMAIT cellspsychological stresssympathetic nervous system

Identifiers

PMID33852855
PMCPMC8112805
OpenAlexW3155539017

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.