ArticleCell reports2021
High-dimensional profiling clusters asthma severity by lymphoid and non-lymphoid status.
Open access · goldAbstract read
In one paragraph
Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- A Research Agenda for Precision Medicine in Sepsis and Acute Respiratory Distress Syndrome: An Official American Thoracic Society Research Statement.American journal of respiratory and critical care medicine · 2021Guideline
- Inhibition of type 1 immunity with tofacitinib is associated with marked improvement in longstanding sarcoidosis.Nature communications · 2022Trial
- Clinical applications of artificial intelligence-driven nitric oxide: a bibliometric and scientific mapping analysis.Medical gas research · 2026Review
- Aberrant mucin expression and keratinization distinguishing severe from mild asthma revealed by interpretable machine learning.JCI insight · 2026Article
- Distinct phenotypes and repertoires of bronchoalveolar and airway mucosal T cells in health and allergic asthma.Mucosal immunology · 2026Article
- Mucosal Remodeling in Chronic Rhinosinusitis with Nasal Polyps: The Role of Innate Lymphoid Cells and Reprogramming Under IL-4Rα Blockade.International journal of molecular sciences · 2026Review
- Comparative effectiveness of omalizumab in asthma-COPD overlap vs. asthma: a retrospective cohort study.Frontiers in medicine · 2026Article
- Differences in Type 2 Phenotype and Clinical Characteristics of Adult Asthma Patients with Different Severity, Across GINA Step 1 to 5 Asthma.Journal of asthma and allergy · 2026Article
- Recombinant RBD-based subunit vaccines incorporating high-frequency mutation sites elicit cross-immunity and robust protection against SARS-CoV-2.Frontiers in microbiology · 2026Article
- Recent Developments in Monoclonal-Antibody-Based Biologic Therapy for Severe Refractory Eosinophilic Asthma.Antibodies (Basel, Switzerland) · 2025Review
- The immunology of asthma and chronic rhinosinusitis.Nature reviews. Immunology · 2025Review
- Circadian Clock Disruption and Non-type 2 Asthma: A Hypothesis-Driven Perspective on Immune, Epithelial, and Steroid Response.Clinical reviews in allergy & immunology · 2025Review
- Rhinovirus as a driver of airway T cell dynamics in children with treatment-refractory recurrent wheeze.JCI insight · 2025Article
- CD8+ TEMRAs in severe asthma associate with asthma symptom duration and escape proliferation arrest.JCI insight · 2025Article
- Lung CD4Cell reports · 2025Article
- T1-T2 Interplay in the Complex Immune Landscape of Severe Asthma.Immunological reviews · 2025Review
- Integrative Roles of Pro-Inflammatory Cytokines on Airway Smooth Muscle Structure and Function in Asthma.Immunological reviews · 2025Review
- Type 1 Immune Responses Related to Viral Infection Influence Corticosteroid Response in Asthma.American journal of respiratory and critical care medicine · 2025Article
- The single-cell revolution in transplantation: high-resolution mapping of graft rejection, tolerance, and injury.Frontiers in immunology · 2025Review
- Epithelial and immune transcriptomic characteristics and possible regulatory mechanisms in asthma exacerbation: insights from integrated studies.Frontiers in immunology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 3 institutions in 1 country.
Matthew J CamioloDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Center for Systems Immunology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Xiaoying ZhouSean N Parker Center for Allergy Research and Division of Pulmonary, Allergy, and Critical Care Medicine, Stanford University, Stanford, CA, USA.
Timothy B OrissDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Qi YanDivision of Pulmonary Medicine, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Michael GorryDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
William HorneRichard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
John B TrudeauDepartment of Environmental Medicine and Occupational Health, Graduate School of Public Health, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Kathryn SchollDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Wei ChenDivision of Pulmonary Medicine, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Jay K KollsDepartment of Medicine and Center for Translational Research in Infection and Inflammation Tulane School of Medicine, New Orleans, LA, USA.
Prabir RayDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Florian J WeiselDepartments of Anesthesiology, Pain, and Peri-operative Medicine and Biomedical Data Sciences, Stanford University, Stanford, CA, USA.
Nadine M WeiselDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Nima AghaeepourDepartments of Anesthesiology, Pain, and Peri-operative Medicine and Biomedical Data Sciences, Stanford University, Stanford, CA, USA.
Kari NadeauSean N Parker Center for Allergy Research and Division of Pulmonary, Allergy, and Critical Care Medicine, Stanford University, Stanford, CA, USA.
Sally E WenzelDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Environmental Medicine and Occupational Health, Graduate School of Public Health, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Anuradha RayDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address: raya@pitt.edu.
University of Pittsburgh · USStanford University · USTulane University · US
Funding
Project 2 Impact of Innate and Adaptive Immunity At the Airway Epithelium in Severe AsthmaP01AI106684 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Wei Chen · 2015 to 2026
$18.9MSEAL (Stopping Atopic dermatitis and ALlergy) Study: Prevent allergy by enhancing the skin barrierU01AI147462 · NIAID · STANFORD UNIVERSITY · PI Mary Johnson, GIDEON LACK · 2020 to 2026
$14.0MMECHANISMS OF ANTIGEN INDUCED TOLERANCE IN THE LUNGR01AI048927 · NIAID · YALE UNIVERSITY · PI RAY, ANURADHA · 2001 to 2020
$8.0MUC Berkeley/Stanford Children's Enviromental Health CenterP01ES022849 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BALMES, JOHN R, HAMMOND, S KATHARINE · 2013 to 2018
$4.2MImplications and Stability of Clinical and Molecular Phenotypes of Severe AsthmaU10HL109152 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WENZEL, SALLY E · 2011 to 2016
$3.9MUnderstanding Severe Asthma Using an Experimental ModelR01HL113956 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RAY, ANURADHA, RAY, PRABIR · 2013 to 2021
$3.5MPhenotyping/Epigenetic studies of PAH-associated Treg impairment in asthmaR01ES020926 · NIEHS · STANFORD UNIVERSITY · PI NADEAU, KARI C. · 2012 to 2016
$2.5MSecondhand smoke and asthma: Mechanistic outcomes of DNA methylation in T cellsR01HL118612 · NHLBI · STANFORD UNIVERSITY · PI MILLER, RACHEL L, NADEAU, KARI C. · 2014 to 2017
$2.3MMachine Learning for Integrative Modeling of the Immune System in Clinical SettingsR35GM138353 · NIGMS · STANFORD UNIVERSITY · PI AGHAEEPOUR, NIMA · 2020 to 2024
$2.2MEffects of IgE Blockade on T Cells in Food AllergyR01AI140134 · NIAID · STANFORD UNIVERSITY · PI NADEAU, KARI C. · 2018 to 2021
$1.6MIL-18 Signaling and Lung Epithelial Cell Barrier Integrity in Severe AsthmaF32HL147415 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CAMIOLO, MATTHEW · 2019 to 2021
$124kNHLBI NIH HHS F32 HL147415NHLBI NIH HHS R01 HL113956NHLBI NIH HHS R01 HL118612NHLBI NIH HHS U10 HL109152NIAID NIH HHS P01 AI106684NIAID NIH HHS R01 AI048927NIAID NIH HHS R01 AI140134NIAID NIH HHS U01 AI147462NIEHS NIH HHS P01 ES022849NIEHS NIH HHS R01 ES020926NIGMS NIH HHS R35 GM138353
Abstract
Clinical definitions of asthma fail to capture the heterogeneity of immune dysfunction in severe, treatment-refractory disease. Applying mass cytometry and machine learning to bronchoalveolar lavage (BAL) cells, we find that corticosteroid-resistant asthma patients cluster largely into two groups: one enriched in interleukin (IL)-4
Indexed as
Machine LearningAdaptive ImmunityAdrenal Cortex HormonesAnti-Asthmatic AgentsAsthmaBronchoalveolar Lavage FluidCase-Control StudiesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesGene Expression ProfilingGene Expression RegulationHumansImmunity, InnateImmunologic MemoryInterferon-gammaInterleukin-10Adrenal Cortex HormonesAnti-Asthmatic AgentsFcepsilonRI alpha-chain, humanIFNG protein, humanIL10 protein, humanIL7 protein, humanInterferon-gammaInterleukin-10Interleukin-7Receptors, IgEBALclustersCyTOFFceRI+ICLiteIFN-gimmunemulti-omicsRNA-seqsevere asthma
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.