Evidence map›Paper›PMID 33852753›Full record

ArticleChemphyschem : a European journal of chemical physics and physical chemistry2021

Magnetic Resonance Detection of Gas Microbubbles via HyperCEST: A Path Toward Dual Modality Contrast Agent.

Christian T McHugh, Phillip G Durham, Michele Kelley, Paul A Dayton, Rosa T Branca

Abstract read
In one paragraph

Article in Chemphyschem : a European journal of chemical physics and physical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. EnhancedMagnetic resonance in medicine · 2023
    Article
  4. Low-boiling Point Perfluorocarbon Nanodroplets as Dual-Phase Dual-Modality MR/US Contrast Agent.Chemphyschem : a European journal of chemical physics and physical chemistry · 2022
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Christian T McHughDepartment of Physics & Astronomy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0001-5668-2088
Phillip G DurhamDepartment of Pharmacoengineering and Molecular Pharmaceutics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Michele KelleyDepartment of Physics & Astronomy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Paul A DaytonBiomedical Research Imaging Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Rosa T BrancaDepartment of Physics & Astronomy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Funding

Sensitive and Specific detection of BAT Tissue and Activity by Magnetic Resonance with Hyperpolarized Xe-129R01DK108231 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BRANCA, ROSA TAMARA · 2015 to 2019
$1.6M
Enabling accurate identification and quantification of brown adipose tissue mass by xenon enhanced computed tomographyR01DK123206 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BRANCA, ROSA TAMARA · 2020 to 2021
$866k
Gas microbubbles as a hyperpolarized-xenon carrier and as a contrast agent for MRIR21EB031319 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BRANCA, ROSA TAMARA · 2021 to 2022
$413k
National Institutes of Diabetes and Digestive and Kidney Diseases R01DK108231National Institutes of Diabetes and Digestive and Kidney Diseases R01DK123206NIBIB NIH HHS R21 EB031319NIBIB NIH HHS R21EB031319NIDDK NIH HHS R01 DK108231NIDDK NIH HHS R01 DK123206
6 · The paper itself

Abstract

Gas microbubbles are an established clinical ultrasound contrast agent. They could also become a powerful magnetic resonance (MR) intravascular contrast agent, but their low susceptibility-induced contrast requires high circulating concentrations or the addition of exogenous paramagnetic nanoparticles for MR detection. In order to detect clinical in vivo concentrations of raw microbubbles via MR, an alternative detection scheme must be used. HyperCEST is an NMR technique capable of indirectly detecting signals from very dilute molecules (concentrations well below the NMR detection threshold) that exchange hyperpolarized

Indexed as

MicrobubblesContrast MediaFluorocarbonsMagnetic Resonance ImagingMagnetic Resonance SpectroscopyXenon IsotopesContrast MediaFluorocarbonsXenon-129Xenon IsotopesbiosensorshyperCESTmicrobubblesNMR spectroscopyxenon

Identifiers

PMID33852753
PMCPMC8494452

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.