ArticlePloS one2021
The gut virome of healthy children during the first year of life is diverse and dynamic.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 48 citations in OpenAlex.
- The enteric DNA virome differs in infants at risk for atopic disease.Gut microbes · 2026Article
- New Insights into the Composition of the Early-Life Gut Microbiome: A Metagenomic Analysis of Fecal Samples in Children Up to 18 Months of Age.Pediatric gastroenterology, hepatology & nutrition · 2026Article
- Article
- The Pathology of Viral Infections.Advances in experimental medicine and biology · 2026Review
- Infant gut anellovirus composition associates with early life factors and childhood atopic disease.Nature communications · 2025Article
- The influence of early life exposures on the infant gut virome.Gut microbes · 2025Article
- Gut virome characteristics associated with early onset of anemia and neurodevelopmental delay in preterm infants.iScience · 2025Article
- Review
- Torque Teno Virus: Lights and Shades.Viruses · 2025Review
- The Role of Infant and Early Childhood Gut Virome in Immunity and the Triggering of Autoimmunity-A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
- Longitudinal phage-bacteria dynamics in the early life gut microbiome.Nature microbiology · 2025Article
- Gut microbiome in the first 1000 days and risk for childhood food allergy.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024Review
- Longitudinal analysis of the enteric virome in paediatric subjects from the Free State Province, South Africa, reveals early gut colonisation and temporal dynamics.Virus research · 2024Article
- Gut virome and diabetes: discovering links, exploring therapies.Archives of microbiology · 2024Review
- Review
- Neonatal Microbiome: Is it Still Beneficial?Endocrine, metabolic & immune disorders drug targets · 2024Article
- Development of systemic and mucosal immune responses against gut microbiota in early life and implications for the onset of allergies.Frontiers in allergy · 2024Review
- Review
- Comparison of gut viral communities in children under 5 years old and newborns.Virology journal · 2023Article
- Normalisation of SARS-CoV-2 concentrations in wastewater: The use of flow, electrical conductivity and crAssphage.The Science of the total environment · 2023Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this work, we determined the diversity and dynamics of the gut virome of infants during the first year of life. Fecal samples were collected monthly, from birth to one year of age, from three healthy children living in a semi-rural village in Mexico. Most of the viral reads were classified into six families of bacteriophages including five dsDNA virus families of the order Caudovirales, with Siphoviridae and Podoviridae being the most abundant. Eukaryotic viruses were detected as early as two weeks after birth and remained present all along the first year of life. Thirty-four different eukaryotic virus families were found, where eight of these families accounted for 98% of all eukaryotic viral reads: Anelloviridae, Astroviridae, Caliciviridae, Genomoviridae, Parvoviridae, Picornaviridae, Reoviridae and the plant-infecting viruses of the Virgaviridae family. Some viruses in these families are known human pathogens, and it is surprising that they were found during the first year of life in infants without gastrointestinal symptoms. The eukaryotic virus species richness found in this work was higher than that observed in previous studies; on average between 7 and 24 virus species were identified per sample. The richness and abundance of the eukaryotic virome significantly increased during the second semester of life, probably because of an increased environmental exposure of infants with age. Our findings suggest an early and permanent contact of infants with a diverse array of bacteriophages and eukaryotic viruses, whose composition changes over time. The bacteriophages and eukaryotic viruses found in these children could represent a metastable virome, whose potential influence on the development of the infant's immune system or on the health of the infants later in life, remains to be investigated.
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