ArticleIEEE transactions on medical imaging2021
Self-Collimating SPECT With Multi-Layer Interspaced Mosaic Detectors.
Article in IEEE transactions on medical imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- A High-Performance Self-Collimation SPECT for Small Animal Imaging.IEEE transactions on medical imaging · 2026Article
- Scatter correction for self-collimating SPECT using a 3D U-Net framework.American journal of nuclear medicine and molecular imaging · 2026Article
- Instrumentation Digital Twins in PET and SPECT Imaging: Current Status, Challenges, and Future Directions.Computational and structural biotechnology journal · 2026Review
- Pre-clinical SPECT and SPECT-CT in Oncology.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026Review
- Low-dose CT for assessing microstructural alterations in Renal Osteodystrophy among uremic patients: a retrospective cohort study.American journal of translational research · 2026Article
- Design optimization and simulated performance evaluation of a self-collimated cardiac SPECT with simultaneous high sensitivity and resolution.Medical physics · 2025Article
- Individual and Simultaneous Imaging ofIEEE transactions on radiation and plasma medical sciences · 2025Article
- A review of state-of-the-art resolution improvement techniques in SPECT imaging.EJNMMI physics · 2025Review
- Recent advances in radionuclide medical imaging techniques.Frontiers in medicine · 2025Review
- Characterization and Assessment of Projection Probability Density Function and Enhanced Sampling in Self-Collimation SPECT.IEEE transactions on medical imaging · 2023Article
- High-sensitivity cardiac SPECT system design with collimator-less interspaced mosaic-patterned scintillators.Frontiers in medicine · 2023Article
- Multi-pinhole collimator design in different numbers of projections for brain SPECT.Frontiers in medicine · 2023Article
- Improvement of Whole-body Bone Planar Images on a Bone-dedicated Single-photon Emission Computed Tomography Scanner by Blind Deconvolution Algorithm.Journal of medical physicsArticle
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Authors and funding
10 authors.
Funding
Abstract
Conventional single photon emission computed tomography (SPECT) relies on mechanical collimation whose resolution and sensitivity are interdependent, the best performance a SPECT system can attain is only a compromise of these two equally desired properties. To simultaneously achieve high resolution and sensitivity, we propose to use sensitive detectors constructed in a multi-layer in ter spaced mosaicdetectors (MATRICES) architecture to accomplish part of the collimation needed. We name this new approach self-collimation. We evaluate three self-collimating SPECT systems and report their imaging performance: 1) A simulated human brain SPECT achieves 3.88% sensitivity, it clearly resolves 0.5-mm and 1.0-mm hot-rod patterns at noise-free and realistic count-levels, respectively; 2) a simulated mouse SPECT achieves 1.25% sensitivity, it clearly resolves 50- [Formula: see text] and 100- [Formula: see text] hot-rod patterns at noise-free and realistic count-levels, respectively; 3) a SPECT prototype achieves 0.14% sensitivity and clearly separates 0.3-mm-diameter point sources of which the center-to-center neighbor distance is also 0.3 mm. Simulated contrast phantom studies show excellent resolution and signal-to-noise performance. The unprecedented system performance demonstrated by these 3 SPECT scanners is a clear manifestation of the superiority of the self-collimating approach over conventional mechanical collimation. It represents a potential paradigm shift in SPECT technology development.
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