Evidence map›Paper›PMID 33852365›Full record

ArticleAmerican journal of physiology. Cell physiology2021

Activation of

Andrew J Nickerson, Trey S Rottgen, Vazhaikkurichi M Rajendran

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Enteric nervous system as a therapeutic target in gastrointestinal disorders.World journal of gastrointestinal pharmacology and therapeutics · 2025
    Article
  2. Article
  3. Review
  4. Review
  5. Bile acids regulate the epithelial NaThe Journal of physiology · 2022
    Article
  6. The Efficacy ofNutrients · 2022
    Article
  7. Beneficial Effects ofFoods (Basel, Switzerland) · 2022
    Article
  8. Flupirtine enhances NHE-3-mediated NaAmerican journal of physiology. Gastrointestinal and liver physiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Andrew J NickersonDepartments of Physiology, Pharmacology and Neuroscience, West Virginia University School of Medicine, Morgantown, West Virginia.
Trey S RottgenDepartments of Physiology, Pharmacology and Neuroscience, West Virginia University School of Medicine, Morgantown, West Virginia.
Vazhaikkurichi M RajendranDepartment of Biochemistry, West Virginia University School of Medicine, Morgantown, West Virginia.ORCID 0000-0002-8999-8721
West Virginia University · US

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI JUDITH FEINBERG · 2012 to 2026
$81.0M
Role of BK Channels in K+-driven Colonic Water Secretion in Health and DiseaseR01DK104791 · NIDDK · WEST VIRGINIA UNIVERSITY · PI RAJENDRAN, VAZHAIKKURICHI M. · 2015 to 2019
$1.7M
Aldosterone Activation of Trans-epithelial Iron Absorption in Human ColonR21DK112085 · NIDDK · WEST VIRGINIA UNIVERSITY · PI RAJENDRAN, VAZHAIKKURICHI M. · 2018 to 2019
$404k
NIDDK NIH HHS R01 DK104791NIDDK NIH HHS R21 DK112085NIGMS NIH HHS U54 GM104942
6 · The paper itself

Abstract

Voltage-gated Kv7 (

Indexed as

AminopyridinesAnimalsCarbacholCell Line, TumorChloridesCholinergic AgonistsColonEnteric Nervous SystemEpithelial CellsFemaleHumansIntestinal MucosaKCNQ Potassium ChannelsMaleMembrane PotentialsMiceAminopyridinesCarbacholChloridesCholinergic AgonistsflupirtineKCNQ Potassium Channelscolonic epitheliumenteric nervous systemflupirtineirritable bowel syndrome with diarrheaUssing chamber

Identifiers

PMID33852365
PMCPMC8285638
OpenAlexW3152799023

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.