Evidence map›Paper›PMID 33852348›Full record

ArticleMolecular biology of the cell2021

Structural insights into the cause of human

Yanhe Zhao, Justine Pinskey, Jianfeng Lin, Weining Yin, Patrick R Sears, Leigh A Daniels, Maimoona A Zariwala, Michael R Knowles, Lawrence E Ostrowski, Daniela Nicastro

Open access · greenAbstract read
In one paragraph

Article in Molecular biology of the cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. BiallelicFrontiers in genetics · 2026
    Article
  3. Review
  4. Compound heterozygousAME case reports · 2026
    Article
  5. Heterogeneity of radial spoke components in Tetrahymena cilia.Cellular and molecular life sciences : CMLS · 2025
    Article
  6. Advances in respiratory medicine · 2025
    Article
  7. Mouse radial spoke 3 is a metabolic and regulatory hub in cilia.Nature structural & molecular biology · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. TheInternational journal of molecular sciences · 2023
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Yanhe ZhaoDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Justine PinskeyDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Jianfeng LinDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Weining YinMarsico Lung Institute, University of North Carolina, Chapel Hill, NC 27599.
Patrick R SearsMarsico Lung Institute, University of North Carolina, Chapel Hill, NC 27599.
Leigh A DanielsMarsico Lung Institute, University of North Carolina, Chapel Hill, NC 27599.
Maimoona A ZariwalaMarsico Lung Institute, University of North Carolina, Chapel Hill, NC 27599.
Michael R KnowlesMarsico Lung Institute, University of North Carolina, Chapel Hill, NC 27599.
Lawrence E OstrowskiMarsico Lung Institute, University of North Carolina, Chapel Hill, NC 27599.
Daniela NicastroDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
The University of Texas Southwestern Medical Center · USLung Institute · USUniversity of North Carolina at Chapel Hill · USEmory University Hospital · US

Funding

The Impact of COVID-19 on People Living with Rare Diseases and Their FamiliesU2CTR002818 · NCATS · CINCINNATI CHILDRENS HOSP MED CTR · PI Maurizio Macaluso, Michael Wagner · 2019 to 2026
$51.2M
Vector CoreP30DK065988 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Richard Charles Boucher, Martina Gentzsch · 2004 to 2026
$26.5M
Longitudinal Characterization of Respiratory Tract Exacerbations and Treatment Responses in Primary Ciliary DyskinesiaU54HL096458 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVIS, STEPHANIE DUGGINS · 2009 to 2023
$20.0M
Pathogenesis of PCD Lung DiseaseR01HL071798 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KNOWLES, MICHAEL R · 2004 to 2021
$7.2M
Structure and Function of Complexes that Regulate Ciliary MotilityR01GM083122 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Daniela Nicastro · 2007 to 2026
$6.2M
Functional Studies of Novel Genes Mutated in Primary Ciliary Dyskinesia II: Genotype to PhenotypeR01HL117836 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI OSTROWSKI, LAWRENCE E · 2013 to 2023
$4.4M
Characterizing three-dimensional structures at the base of primary and motile cilia using cryo-electron tomographyF32GM137470 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI PINSKEY, JUSTINE MARIE · 2020 to 2022
$154k
NCATS NIH HHS U2C TR002818NHLBI NIH HHS R01 HL071798NHLBI NIH HHS R01 HL117836NHLBI NIH HHS U54 HL096458NIDDK NIH HHS P30 DK065988NIGMS NIH HHS F32 GM137470NIGMS NIH HHS R01 GM083122
6 · The paper itself

Abstract

Cilia and flagella are evolutionarily conserved eukaryotic organelles involved in cell motility and signaling. In humans, mutations in Radial Spoke Head Component 4A (

Indexed as

AxonemeCiliaCiliary Motility DisordersCytoskeletal ProteinsElectron Microscope TomographyHumansMutationRespiratory SystemCytoskeletal ProteinsRSPH4A protein, human

Identifiers

PMID33852348
PMCPMC8351563
OpenAlexW3154913609

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.