ArticleMolecular systems biology2021
Global coordination of metabolic pathways in Escherichia coli by active and passive regulation.
Article in Molecular systems biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Coarse-grained resource allocation modeling for decoding and rewiring microbial metabolism.Trends in microbiology · 2026Review
- Atomic elementary flux modes explain the steady state flow of metabolites in large-scale flux networks.Cell reports methods · 2026Article
- Single-cell heterogeneity in ribosome levels and protein synthesis during nutrient starvation is driven by cAMP signaling.Science advances · 2026Article
- Inorganic Carbon Modulates Emulsification Activity and Transcriptional Responses inMolecules (Basel, Switzerland) · 2026Article
- Modulating 6 S RNA improves recombinant protein yield in Escherichia coli at lower temperatures.World journal of microbiology & biotechnology · 2026Article
- Matters of life and death in computational cell biology.NPJ systems biology and applications · 2026Review
- Identification of antimicrobial resistance genes in Escherichia coli through network diffusion.The Journal of antimicrobial chemotherapy · 2026Article
- Integrated genomic-transcriptomic analysis of clavulanic acid production in differentially productive Streptomyces clavuligerus strains.Scientific reports · 2025Article
- Article
- Bacterial cell wall biosynthesis is controlled by growth rate dependent modulation of turgor pressure inbioRxiv : the preprint server for biology · 2025Article
- cAMP-independent Crp homolog adds to the multi-layer regulatory network inFrontiers in cellular and infection microbiology · 2025Article
- Yeast9: a consensus genome-scale metabolic model for S. cerevisiae curated by the community.Molecular systems biology · 2024Article
- Evolution and stability of complex microbial communities driven by trade-offs.Molecular systems biology · 2024Review
- Shaping of microbial phenotypes by trade-offs.Nature communications · 2024Review
- Proteome partitioning constraints in long-term laboratory evolution.Nature communications · 2024Article
- Homeostasis of cytoplasmic crowding by cell wall fluidization and ribosomal counterions.Research square · 2024Article
- A parallel glycolysis provides a selective advantage through rapid growth acceleration.Nature chemical biology · 2024Article
- Tradeoffs in bacterial physiology determine the efficiency of antibiotic killing.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Design of a sorbitol-activated nitrogen metabolism-dependent regulatory system for redirection of carbon metabolism flow in Bacillus licheniformis.Nucleic acids research · 2023Article
- Local flux coordination and global gene expression regulation in metabolic modeling.Nature communications · 2023Article
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6 authors.
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Abstract
Microorganisms adjust metabolic activity to cope with diverse environments. While many studies have provided insights into how individual pathways are regulated, the mechanisms that give rise to coordinated metabolic responses are poorly understood. Here, we identify the regulatory mechanisms that coordinate catabolism and anabolism in Escherichia coli. Integrating protein, metabolite, and flux changes in genetically implemented catabolic or anabolic limitations, we show that combined global and local mechanisms coordinate the response to metabolic limitations. To allocate proteomic resources between catabolism and anabolism, E. coli uses a simple global gene regulatory program. Surprisingly, this program is largely implemented by a single transcription factor, Crp, which directly activates the expression of catabolic enzymes and indirectly reduces the expression of anabolic enzymes by passively sequestering cellular resources needed for their synthesis. However, metabolic fluxes are not controlled by this regulatory program alone; instead, fluxes are adjusted mostly through passive changes in the local metabolite concentrations. These mechanisms constitute a simple but effective global regulatory program that coarsely partitions resources between different parts of metabolism while ensuring robust coordination of individual metabolic reactions.
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