ReviewPediatric nephrology (Berlin, Germany)2022
Early microvascular complications in type 1 and type 2 diabetes: recent developments and updates.
Review in Pediatric nephrology (Berlin, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Risk factors for the occurrence and progression of diabetic retinopathy in children and adolescents: a systematic review and meta-analysis.Frontiers in public health · 2026Pooled it
- Type 1 diabetes and the risk of epilepsy: A meta-analysis.Journal of diabetes investigation · 2024Pooled it
- ISPAD Clinical Practice Consensus Guidelines 2024: Type 2 Diabetes in Children and Adolescents.Hormone research in paediatrics · 2024Guideline
- Clinical modifiers of the association between type 1 diabetes and dementia incidence.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Factors associated with preventive behaviors for microvascular complications and self-reported neuropathy symptoms among community-dwelling individuals with type 2 diabetes in Thailand.BMC public health · 2026Article
- Potential Causal Relationship Between Hypertension and Type 2 Diabetic Nephropathy: Integrating Mendelian Randomization Evidence with Global Burden of Disease 2021 Analysis.Healthcare (Basel, Switzerland) · 2026Article
- Periodontal Inflammatory Burden and Multi-Organ Microvascular Impairment in Type 2 Diabetes: A Cross-Sectional Observational Study.Current issues in molecular biology · 2026Article
- Genetic Determinants of Microvascular Complications of Type 1 Diabetes Mellitus: New Data from a Replication Study.Biomedicines · 2026Article
- Outcomes in youth-onset type 2 diabetes during the transition period: glycemic control, microvascular complications, and effects of second-line agents.Annals of pediatric endocrinology & metabolism · 2026Article
- Article
- The Natural History of Prediabetes and Cardiovascular Disease in the Pediatric Population.Biomedicines · 2026Review
- Development and validation of a prediction model for microvascular complications of type 2 diabetes based on inflammation-metabolism composite indicators.Frontiers in endocrinology · 2026Article
- Article
- Dynamics of Urine Metabolomics and Tubular Inflammatory Cytokines in Type 1 Diabetes Across Disease Durations.Metabolites · 2025Article
- Metabolic disorders in young people around the world.Diabetologia · 2025Review
- Overexpression of PON1 reduces high glucose induced renal tubular epithelial cell injury by activating PPARγ signaling pathway to alleviate diabetes nephropathy.Archives of endocrinology and metabolism · 2025Article
- Gastric filling ultrasound in assessing gastrointestinal motility in type 2 diabetic patients with neuropathy: A clinical study.Journal of diabetes investigation · 2025Article
- Ocular findings in children, adolescents and young adults with type 1 diabetes mellitus in ghana: a cross-sectional study.BMC ophthalmology · 2025Article
- Could MOTS-c Levels in Children with Type 1 Diabetes Mellitus Be an Indicator for Early Diabetic Kidney Disease?Journal of clinical research in pediatric endocrinology · 2025Article
- Home self monitoring of blood glucose using a glucometer and its determinants among diabetes mellitus.Scientific reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The prevalence of youth-onset diabetes is progressing rapidly worldwide, and poor glycemic control, in combination with prolonged diabetes duration and comorbidities including hypertension, has led to the early development of microvascular complications including diabetic kidney disease, retinopathy, and neuropathy. Pediatric populations with type 1 (T1D) and type 2 (T2D) diabetes are classically underdiagnosed with microvascular complications, and this leads to both undertreatment and insufficient attention to the mitigation of risk factors that could help attenuate further progression of complications and decrease the likelihood for long-term morbidity and mortality. This narrative review aims to present a comprehensive summary of the epidemiology, risk factors, symptoms, screening practices, and treatment options, including future opportunities for treatment advancement, for microvascular complications in youth with T1D and T2D. We seek to uniquely focus on the inherent challenges of managing pediatric populations with diabetes and discuss the similarities and differences between microvascular complications in T1D and T2D, while presenting a strong emphasis on the importance of early identification of at-risk youth. Further investigation of possible treatment mechanisms for microvascular complications in youth with T1D and T2D through dedicated pediatric outcome trials is necessary to target the brief window where early pathological vascular changes may be significantly attenuated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.