ArticleInternational urogynecology journal2022
Urinary microbiota of women with recurrent urinary tract infection: collection and culture methods.
Article in International urogynecology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 35 citations in OpenAlex.
- Characterizing the role of the urobiome in the pathogenesis of recurrent urinary tract infections (rUTIs): a systematic review.International urology and nephrology · 2026Review
- The Urogenital Microbiome-Metabolic Interface in Postmenopausal Recurrent Urinary Tract Infection: Estrogen Deficiency, Diabetes, Obesity, and Microbial Reservoirs.Journal of clinical medicine · 2026Review
- Longitudinal Impact of Methenamine Hippurate on the Urobiome of Postmenopausal Women With Recurrent UTIs.International urogynecology journal · 2026Article
- Differential antimicrobial responses in polymicrobial triple-species biofilms associated with persistent urinary tract infections.Scientific reports · 2026Article
- More than an infection: the ecological puzzle of recurrent urinary tract infections.Frontiers in cellular and infection microbiology · 2026Review
- Complete genome sequence of vaginal swab isolateMicrobiology resource announcements · 2025Article
- Utility of enhanced quantitative urine culture technique for isolation of uro-pathogens in children.Journal of family medicine and primary care · 2025Article
- Rapid and accurate testing for urinary tract infection: new clothes for the emperor.Clinical microbiology reviews · 2025Review
- Characterizing the urobiome in geriatric males with chronic indwelling urinary catheters: an exploratory longitudinal study.Microbiology spectrum · 2024Article
- Draft genomes ofMicrobiology resource announcements · 2024Article
- Draft genomes ofMicrobiology resource announcements · 2024Article
- Draft genome sequences of fourMicrobiology resource announcements · 2024Article
- Draft genomes of oneMicrobiology resource announcements · 2024Article
- Turbidimetric bioassays: A solution to antimicrobial activity detection in asymptomatic bacteriuria isolates against uropathogenic Escherichia coli.MicrobiologyOpen · 2024Article
- Synthesis of current pediatric urinary microbiome research.Frontiers in pediatrics · 2024Review
- Pyuria in hospitalized general medical patients without urinary tract infection.F1000Research · 2024Article
- Comparative genomic analysis of clinical Enterococcus faecalis distinguishes strains isolated from the bladder.BMC genomics · 2023Article
- Nanotechnology Involved in Treating Urinary Tract Infections: An Overview.Nanomaterials (Basel, Switzerland) · 2023Review
- Cataloging variation in 16S rRNA gene sequences of female urobiome bacteria.Frontiers in urology · 2023Article
- Tarnished gold-the "standard" urine culture: reassessing the characteristics of a criterion standard for detecting urinary microbes.Frontiers in urology · 2023Review
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
introduction and hypothesisMany clinicians utilize standard culture of voided urine to guide treatment for women with recurrent urinary tract infections (RUTI). However, despite antibiotic treatment, symptoms may persist and events frequently recur. The cyclic nature and ineffective treatment of RUTI suggest that underlying uropathogens pass undetected because of the preferential growth of Escherichia coli. Expanded quantitative urine culture (EQUC) detects more clinically relevant microbes. The objective of this study was to assess how urine collection and culture methods influence microbial detection in RUTI patients.
methodsThis cross-sectional study enrolled symptomatic adult women with an established RUTI diagnosis. Participants contributed both midstream voided and catheterized urine specimens for culture via both standard urine culture (SUC) and EQUC. Presence and abundance of microbiota were compared between culture and collection methods.
resultsForty-three symptomatic women participants (mean age 67 years) contributed specimens. Compared to SUC, EQUC detected more unique bacterial species and consistently detected more uropathogens from catheterized and voided urine specimens. For both collection methods, the most commonly detected uropathogens by EQUC were E. coli (catheterized: n = 8, voided: n = 12) and E. faecalis (catheterized: n = 7, voided: n = 17). Compared to catheterized urine samples assessed by EQUC, SUC often missed uropathogens, and culture of voided urines by either method yielded high false-positive rates.
conclusionsIn women with symptomatic RUTI, SUC and assessment of voided urines have clinically relevant limitations in uropathogen detection. These results suggest that, in this population, catheterized specimens analyzed via EQUC provide clinically relevant information for appropriate diagnosis.
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