ArticleeLife2021
Circuit organization of the excitatory sensorimotor loop through hand/forelimb S1 and M1.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07150325 (Integration of Force Control Training and Mirror Visual Feedback on Stroke Patients on Brain Activation and Hand Function), which is not on this map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Integration of Force Control Training and Mirror Visual Feedback on Stroke Patients on Brain Activation and Hand Function
Who cites it
36 citing papers in PubMed.
- Prioritized nonlinear modeling of shared dynamics across neural populations.Journal of neural engineering · 2026Article
- Somatosensory input drives membrane potential dynamics in motor cortex during voluntary limb movement.PLoS biology · 2026Article
- Circuit Organization of the Forelimb-Related M2-to-M1 Corticocortical Pathway in the Mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Mouse sensorimotor cortex reflects complex kinematic details during reaching and grasping.eLife · 2026Article
- Circuit organization of the forelimb-related M2-to-M1 corticocortical pathway in the mouse.bioRxiv : the preprint server for biology · 2026Article
- Cell type-specific plasticity in synaptic, intrinsic, and sound response properties of deep-layer cortical neurons after noise trauma.Science advances · 2025Article
- Cortical dynamics in hand/forelimb S1 and M1 evoked by brief photostimulation of the mouse's hand.eLife · 2025Article
- Article
- Syngap1 promotes cognitive function through regulation of cortical sensorimotor dynamics.Nature communications · 2025Article
- Somatosensory-evoked response induces extensive diffusivity and kurtosis changes associated with neural activity in rodents.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Beyond Barrels: Diverse Thalamocortical Projection Motifs in the Mouse Ventral Posterior Complex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- Interactions between arm and leg neuronal circuits following paired cervical and lumbosacral transspinal stimulation in healthy humans.Experimental brain research · 2024Article
- Human tactile sensing and sensorimotor mechanism: from afferent tactile signals to efferent motor control.Nature communications · 2024Article
- Functional architecture of the forebrain cholinergic system in rodents.Research square · 2024Article
- Selective plasticity of layer 2/3 inputs onto distal forelimb controlling layer 5 corticospinal neurons with skilled grasp motor training.Cell reports · 2024Article
- The functional and anatomical characterization of three spinal output pathways of the anterolateral tract.Cell reports · 2024Article
- The secondary somatosensory cortex gates mechanical and heat sensitivity.Nature communications · 2024Article
- Corticospinal Modulation of Precision Movements.Neuroscience insights · 2024Article
- An operating principle of the cerebral cortex, and a cellular mechanism for attentional trial-and-error pattern learning and useful classification extraction.Frontiers in neural circuits · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Sensory-guided limb control relies on communication across sensorimotor loops. For active touch with the hand, the longest loop is the transcortical continuation of ascending pathways, particularly the lemnisco-cortical and corticocortical pathways carrying tactile signals via the cuneate nucleus, ventral posterior lateral (VPL) thalamus, and primary somatosensory (S1) and motor (M1) cortices to reach corticospinal neurons and influence descending activity. We characterized excitatory connectivity along this pathway in the mouse. In the lemnisco-cortical leg, disynaptic cuneate→VPL→S1 connections excited mainly layer (L) 4 neurons. In the corticocortical leg, S1→M1 connections from L2/3 and L5A neurons mainly excited downstream L2/3 neurons, which excite corticospinal neurons. The findings provide a detailed new wiring diagram for the hand/forelimb-related transcortical circuit, delineating a basic but complex set of cell-type-specific feedforward excitatory connections that selectively and extensively engage diverse intratelencephalic projection neurons, thereby polysynaptically linking subcortical somatosensory input to cortical motor output to spinal cord.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.