ReviewScandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society2021
Diagnosis of Uncomplicated and Complicated Appendicitis in Adults.
Review in Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 3 of them syntheses that pooled it.
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Who cites it
64 citing papers in PubMed, 3 syntheses or guidelines pooled it, 139 citations in OpenAlex.
- Ultrasound and computed tomography in differentiating between simple and complicated appendicitis in pediatric patients.Pediatric surgery international · 2024Pooled it
- SAGES guideline for the diagnosis and treatment of appendicitis.Surgical endoscopy · 2024Guideline
- Hyponatremia as a predictor of complicated appendicitis: a systematic review and meta-analysis.Biomarkers in medicine · 2024Pooled it
- Antibiotics versus placebo in adults with CT-confirmed uncomplicated acute appendicitis (APPAC III): randomized double-blind superiority trial.The British journal of surgery · 2022Trial
- A three-dimensional framework for acute appendicitis integrating etiology, pathological severity, and host response.Annals of medicine and surgery (2012) · 2026Article
- The utility of HALP, M-HALP, and the newly developed CANP scores in predicting prognosis of acute appendicitis.Updates in surgery · 2026Article
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- Article
- Impact of Disease Severity and Age on Outcomes After Laparoscopic Versus Open Appendectomy: A Single-Center Retrospective Cohort Study.Life (Basel, Switzerland) · 2026Article
- Non-operative Management of Uncomplicated Appendicitis: A Review of Indications, Safety, and Clinical Algorithms.Cureus · 2026Review
- Evaluation of the predictive value of scoring systems in diagnosis of acute appendicitis: a comparative prospective study.Langenbeck's archives of surgery · 2026Article
- Article
- Low-keV virtual monoenergetic images with rapid kilovoltage-switching DECT for differentiating complicated from uncomplicated appendicitis in adults.Abdominal radiology (New York) · 2026Article
- A Hybrid Model with Quantum Feature Map Based on CNN and Vision Transformer for Clinical Support in Diagnosis of Acute Appendicitis.Biomedicines · 2026Article
- Article
- The Role of Emerging Immune-Inflammatory Indexes in the Preoperative Differentiation of Complicated and Uncomplicated Acute Appendicitis: A Single-Center Retrospective Analysis.Diagnostics (Basel, Switzerland) · 2025Article
- Artificial intelligence in acute appendicitis: A comprehensive review of machine learning and deep learning applications.World journal of gastroenterology · 2025Review
- Appendicitis.Nature reviews. Disease primers · 2025Review
- Neutrophil percentage-to-albumin ratio for preoperative risk stratification of complicated appendicitis in children: a retrospective study.BMC gastroenterology · 2025Article
- Progress in the application of machine learning in CT diagnosis of acute appendicitis.Abdominal radiology (New York) · 2025Review
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiagnostic work-up of acute appendicitis remains challenging. While some guidelines advise to use a risk stratification based on clinical parameters, others use standard imaging in all patients. As non-operative management of uncomplicated appendicitis has been identified as feasible and safe, differentiation between uncomplicated and complicated appendicitis is of paramount importance. We reviewed the literature to describe the optimal strategy for diagnosis of acute appendicitis.
methodsA narrative review about the diagnosis of acute appendicitis in adult patients was conducted. Both diagnostic strategies and goals were analyzed.
resultsFor diagnosing acute appendicitis, both ruling in and ruling out the disease are important. Clinical and laboratory findings individually do not suffice, but when combined in a diagnostic score, a better risk prediction can be made for having acute appendicitis. However, for accurate diagnosis imaging seems obligatory in patients suspected for acute appendicitis. Scoring systems combining clinical and imaging features may differentiate between uncomplicated and complicated appendicitis and may enable ruling out complicated appendicitis. Within conservatively treated patients with uncomplicated appendicitis, predictive factors for non-responsiveness to antibiotics and recurrence of appendicitis need to be defined in order to optimize treatment outcomes.
conclusionStandard imaging increases the diagnostic power for both ruling in and ruling out acute appendicitis. Incorporating imaging features in clinical scoring models may provide better differentiation between uncomplicated and complicated appendicitis. Optimizing patient selection for antibiotic treatment of appendicitis may minimize recurrence rates, resulting in better treatment outcomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.