ArticleEnvironmental health perspectives2021
Assessing Indoor Dust Interference with Human Nuclear Hormone Receptors in Cell-Based Luciferase Reporter Assays.
Article in Environmental health perspectives, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 38 citations in OpenAlex.
- SynergisticiScience · 2026Article
- Integrative network toxicology and molecular docking reveal epigenetic and endocrine-disrupting mechanisms of PFAS in ovarian cancer.Frontiers in pharmacology · 2026Article
- Associations between organophosphate flame retardants metabolites in follicular fluid and reproductive outcomes among women undergoing IVF/ICSI treatment in Southwest China.Reproductive biology and endocrinology : RB&E · 2025Article
- Adverse outcome pathway for the neurotoxicity of Per- and polyfluoroalkyl substances: A systematic review.Eco-Environment & Health · 2024Review
- Sex-specific effects of organophosphate ester exposure on child growth trajectories in the first two years.Eco-Environment & Health · 2023Article
- Organophosphate Esters Disrupt Steroidogenesis in KGN Human Ovarian Granulosa Cells.Endocrinology · 2023Article
- Hormone receptor activities of complex mixtures of known and suspect chemicals in personal silicone wristband samplers worn in office buildings.Chemosphere · 2023Article
- How the Structure of Per- and Polyfluoroalkyl Substances (PFAS) Influences Their Binding Potency to the Peroxisome Proliferator-Activated and Thyroid Hormone Receptors-An In Silico Screening Study.Molecules (Basel, Switzerland) · 2023Article
- Early life organophosphate ester exposures and bone health at age 12 years: The Health Outcomes and Measures of the Environment (HOME) Study.The Science of the total environment · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundPer- and polyfluoroalkyl substances (PFAS), organophosphate esters (OPEs), and polybrominated diphenyl ethers (PBDEs) are hormone-disrupting chemicals that migrate from building materials into air and dust.
objectivesWe aimed to quantify the hormonal activities of 46 dust samples and identify chemicals driving the observed activities.
methodsWe evaluated associations between hormonal activities of extracted dust in five cell-based luciferase reporter assays and dust concentrations of 42 measured PFAS, OPEs, and PBDEs, transformed as either raw or potency-weighted concentrations based on Tox21 high-throughput screening data.
resultsAll dust samples were hormonally active, showing antagonistic activity toward peroxisome proliferator-activated receptor ( DISCUSSION: All indoor dust samples exhibited hormonal activities, which were associated with PFAS, PBDE, and OPE levels. Reporter gene cell-based assays are relatively inexpensive, health-relevant evaluations of toxic loads of chemical mixtures that building occupants are exposed to. https://doi.org/10.1289/EHP8054.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.