Evidence map›Paper›PMID 33851749›Full record

ArticleJournal of medical virology2021

Prolonged presence of replication-competent SARS-CoV-2 in mildly symptomatic individuals: A report of two cases.

Maria C Mendes Correa, Fabio E Leal, Lucy S Villas Boas, Steven S Witkin, Anderson de Paula, Tania R Tozetto Mendonza, Noely E Ferreira, Gislaine Curty, Pedro S de Carvalho, Lewis F Buss and 11 more

Abstract readCase Reports
In one paragraph

Article in Journal of medical virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Maria C Mendes CorreaLaboratorio de Investigacao Medica em Virologia (LIM52), Instituto de Medicina Tropical de Sao Paulo, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, Brazil.ORCID 0000-0001-5655-8108
Fabio E LealFaculdade de Medicina, Universidade Municipal de Sao Caetano do Sul, São Caetano do Sul, São Paulo, Brazil.
Lucy S Villas BoasLaboratorio de Investigacao Medica em Virologia (LIM52), Instituto de Medicina Tropical de Sao Paulo, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, Brazil.
Steven S WitkinLaboratorio de Investigacao Medica em Virologia (LIM52), Instituto de Medicina Tropical de Sao Paulo, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, Brazil.
Anderson de PaulaLaboratorio de Investigacao Medica em Virologia (LIM52), Instituto de Medicina Tropical de Sao Paulo, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, Brazil.
Tania R Tozetto MendonzaLaboratorio de Investigacao Medica em Virologia (LIM52), Instituto de Medicina Tropical de Sao Paulo, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, Brazil.ORCID 0000-0002-5659-1052
Noely E FerreiraLaboratorio de Investigacao Medica em Virologia (LIM52), Instituto de Medicina Tropical de Sao Paulo, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, Brazil.
Gislaine CurtyInstituto Nacional do Cancer Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
Pedro S de CarvalhoInstituto Nacional do Cancer Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
Lewis F BussDepartamento de Molestias Infecciosas e Parasitarias da Faculdade de Medicina, Universidade de São Paulo, São Paulo, São Paulo, Brazil.
Silvia F CostaDepartamento de Molestias Infecciosas e Parasitarias da Faculdade de Medicina, Universidade de São Paulo, São Paulo, São Paulo, Brazil.
Flavia M da Cunha CarvalhoInstituto de Medicina Tropical de Sao Paulo, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, São Paulo, Brazil.
Joyce KawakamiInstituto do Coracao do Hospital das Clinicas da Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, São Paulo, Brazil.
Noemi N TaniwakiInstituto Adolf Lutz de São Paulo, São Paulo, São Paulo, Brazil.
Heuder PaiaoLaboratorio de Investigacao Medica em Virologia (LIM52), Instituto de Medicina Tropical de Sao Paulo, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, Brazil.
Joao C da Silva BizárioFaculdade de Medicina, Universidade Municipal de Sao Caetano do Sul, São Caetano do Sul, São Paulo, Brazil.
Jaqueline G de JesusDepartamento de Molestias Infecciosas e Parasitarias da Faculdade de Medicina, Universidade de São Paulo, São Paulo, São Paulo, Brazil.
Ester C SabinoDepartamento de Molestias Infecciosas e Parasitarias da Faculdade de Medicina, Universidade de São Paulo, São Paulo, São Paulo, Brazil.
Camila M RomanoLaboratorio de Investigacao Medica em Virologia (LIM52), Instituto de Medicina Tropical de Sao Paulo, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, Brazil.
Regina M Z GrepanFaculdade de Medicina, Universidade Municipal de Sao Caetano do Sul, São Caetano do Sul, São Paulo, Brazil.
Antonio SessoInstituto de Medicina Tropical de Sao Paulo, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, São Paulo, Brazil.

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo FAPESP (2020/05623-0)
6 · The paper itself

Abstract

It has been estimated that individuals with COVID-19 can shed replication-competent virus up to a maximum of 20 days after initiation of symptoms. The majority of studies that addressed this situation involved hospitalized individuals and those with severe disease. Studies to address the possible presence of SARS-CoV-2 during the different phases of COVID-19 disease in mildly infected individuals, and utilization of viral culture techniques to identify replication-competent viruses, have been limited. This report describes two patients with mild forms of the disease who shed replication-competent virus for 24 and 37 days, respectively, after symptom onset.

Indexed as

Virus CultivationAnimalsChlorocebus aethiopsCOVID-19FemaleHumansMiddle AgedSARS-CoV-2Vero CellsViral LoadVirus Sheddingcell culturecoronavirusSARS-CoV-2

Identifiers

PMID33851749
PMCPMC8250959

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.