Evidence map›Paper›PMID 33851355›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2022

Predictive value of incidental right ventricular abnormalities identified on SPECT for mortality and pulmonary hypertension.

Arun Jose, Christine Zhou, Rachel Baker, Jackson Walker, Nicholas Kurek, Robert E O'Donnell, Jean M Elwing, Myron Gerson

Open access · greenAbstract read
In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Revisiting Perfusion in the Forgotten Right Ventricle: Artificial Intelligence-Enhanced Quantification on PET/CT.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  2. Article
  3. Review of cardiovascular imaging in the Journal of Nuclear Cardiology 2022: single photon emission computed tomography.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Arun JoseDivision of Pulmonary, Critical Care, and Sleep Medicine, University of Cincinnati College of Medicine, 6352-A, Medical Sciences Building, 231 Albert Sabin Way, Cincinnati, OH, 45267, USA. josean@ucmail.uc.edu.
Christine ZhouDivision of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Rachel BakerUndergraduate Studies, University of Cincinnati College of Arts and Sciences, Cincinnati, OH, USA.
Jackson WalkerDivision of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Nicholas KurekDivision of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Robert E O'DonnellDivision of Cardiovascular Diseases, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Jean M ElwingDivision of Pulmonary, Critical Care, and Sleep Medicine, University of Cincinnati College of Medicine, 6352-A, Medical Sciences Building, 231 Albert Sabin Way, Cincinnati, OH, 45267, USA.
Myron GersonDivision of Cardiovascular Diseases, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
University of Cincinnati Medical Center · USSabin Vaccine Institute · US

Funding

LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI MEINZEN-DERR, JAREEN, STRAWN, JEFFREY ROBERT · 2015 to 2024
$37.5M
NCATS NIH HHS UL1 TR001425
6 · The paper itself

Abstract

backgroundThe clinical significance of incidentally found RV abnormalities on low-risk SPECT studies is not well-defined. The objective of this study was to determine the predictive value of incidental right ventricular (RV) abnormalities identified on single photon emission computed tomography (SPECT) scans for mortality and pulmonary hypertension (PH).

methodsWe retrospectively analyzed all low-risk SPECT studies in patients without known coronary artery or pulmonary vascular disease, performed at our institution, from 2007-2020. Adjusted Cox proportional hazards models were used to evaluate the association between incidental RV abnormalities on low-risk SPECT studies and outcomes.

resultsOf the 4761 patients included in the analysis, mortality events were present in 494, and echocardiographic PH was present in 619. Incidental RV abnormalities on low-risk SPECT studies were significantly and independently associated with all-cause mortality (HR = 1.41, CI [1.07-1.86], P = 0.0152) and echocardiographic PH (HR = 2.06, CI [1.64-2.60], P < 0.0001).

conclusionsThese data suggest incidental RV abnormalities found on low-risk SPECT imaging studies are significantly and independently associated with increased mortality and risk of developing echocardiographic PH, and could identify high-risk patients for closer monitoring and additional diagnostic testing.

Indexed as

Heart Defects, CongenitalHypertension, PulmonaryVentricular Dysfunction, RightEchocardiographyHumansPrognosisProportional Hazards ModelsRetrospective StudiesTomography, Emission-Computed, Single-PhotonVentricular Function, Right

Identifiers

PMID33851355
PMCPMC8043660
OpenAlexW3155050801

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.