SynthesisJournal of bone and mineral metabolism2021
Impact of high-load resistance training on bone mineral density in osteoporosis and osteopenia: a meta-analysis.
Synthesis in Journal of bone and mineral metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 8 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Acute and Chronic Effects of Accentuated Eccentric Loading vs. Constant-Load Resistance Training: A Systematic Review and Meta-analysis.Sports medicine (Auckland, N.Z.) · 2026Pooled it
- Effect of exercise on bone-related outcomes in patients with cancer affected by bone metastases or bone loss: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Pooled it
- Systematic review and meta-analysis of the effects of blood flow restriction training on bone health in older adults.Scientific reports · 2025Pooled it
- Optimization of high-intensity resistance exercise protocols for improving bone mineral density in the elderly without chronic diseases: a systematic review and network meta-analysis.Frontiers in physiology · 2025Pooled it
- The effect of different traditional Chinese exercises on bone mineral density in menopausal women: a systematic review and network meta-analysis.Frontiers in public health · 2024Pooled it
- Effects of blood flow restriction training on bone metabolism: a systematic review and meta-analysis.Frontiers in physiology · 2023Pooled it
- Osteoporosis in COPD patients: Risk factors and pulmonary rehabilitation.The clinical respiratory journal · 2022Pooled it
- The effect and safety of Tai Chi on bone health in postmenopausal women: A meta-analysis and trial sequential analysis.Frontiers in aging neuroscience · 2022Pooled it
- Effect of different types of Tai Chi exercise programs on the rate of change in bone mineral density in middle-aged adults at risk of osteoporosis: a randomized controlled trial.Journal of orthopaedic surgery and research · 2023Trial
- Systematic Review of Exercise Interventions and HRQOL in Predialysis CKD.Kidney international reports · 2026Article
- Accelerometer-measured weekly and diurnal moderate-to-vigorous physical activity patterns and incident osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Review
- Meeting the WHO guideline on muscle-strengthening activities does not have to be time-consuming: a discussion of time-saving strategies.Frontiers in public health · 2026Article
- Brief, Low-impact, High-intensity Osteogenic Loading in Postmenopausal Osteoporosis: A Quasi-experimental Case-series Study.The Journal of clinical endocrinology and metabolism · 2025Article
- Exercise for Postmenopausal Bone Health - Can We Raise the Bar?Current osteoporosis reports · 2025Review
- Enhancing resistance training adherence in older adults with sarcopenia or osteoporosis: a study on referral success rates.Frontiers in public health · 2025Article
- Walking pace and its association with osteoporosis and pathological fractures: insights from UK biobank.Frontiers in endocrinology · 2025Article
- Association between muscle-localized bioelectrical impedance analysis parameters and performance in a multi-set exercise on the isokinetic dynamometer in young women.European journal of sport science · 2024Article
- Idiosyncratic bone responses to blood flow restriction exercise: new insights and future directions.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Review
- EmpowerHER: A Pilot Study to Increase Physical Activity and Strength Through Powerbuilding.International journal of exercise science · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
introductionThis study aimed to examine the effect of high-load resistance training (HLRT) on bone mineral density (BMD) in patients with osteoporosis and osteopenia using a meta-analysis. MATERIALS AND
methodsWe searched for randomized controlled trials (RCTs) on HLRT in patients with osteoporosis and osteopenia from medical databases. Our meta-analysis was performed with the primary endpoints being the standardized mean difference (SMD) of the change in BMD of the lumbar spine (LS), femoral neck (FN), and total hip (TH). The robustness of the results was assessed by subgroup analysis. Heterogeneity factors were examined by meta-regression. Publication bias was evaluated using a funnel plot.
resultsWe selected nine RCTs, with 259 patients in the HLRT group (women, 55.2%) and 236 patients in the control group (women, 62.7%). The HLRT group showed a significant increase in BMD in the LS [SMD = 1.40, 95% confidence interval (CI) = 0.68-2.12, p < 0.001, I
conclusionThis study suggested that HLRT can be effective in increasing BMD, mainly of LS, in patients with osteoporosis and osteopenia. However, due to high heterogeneity and publication bias, additional studies with a low risk of bias should be conducted to generalize our findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.