Evidence map›Paper›PMID 33851166›Full record

ArticlebioRxiv : the preprint server for biology2021

Polymersomes decorated with SARS-CoV-2 spike protein receptor binding domain elicit robust humoral and cellular immunity.

Lisa R Volpatti, Rachel P Wallace, Shijie Cao, Michal M Raczy, Ruyi Wang, Laura T Gray, Aaron T Alpar, Priscilla S Briquez, Nikolaos Mitrousis, Tiffany M Marchell and 20 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 11 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

30 authors at 4 institutions in 1 country.

Lisa R Volpatti *Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States.
Rachel P Wallace *Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States.
Shijie Cao *Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States.
Michal M Raczy *Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States.
Ruyi Wang *Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States.
Laura T GrayPritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States.
Aaron T AlparPritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States.
Priscilla S BriquezPritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States.
Nikolaos MitrousisPritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States.
Tiffany M MarchellCommittee on Immunology, University of Chicago, Chicago, IL 60637, United States.
Maria Stella SassoPritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States.
Mindy NguyenPritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States.
Aslan MansurovPritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States.
Erica BudinaPritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States.
Ani SolankiAnimal Resources Center, University of Chicago, Chicago, IL 60637, United States.
Elyse A WatkinsPritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States.
Mathew R SchnorenbergPritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States.
Andrew C TremainCommittee on Immunology, University of Chicago, Chicago, IL 60637, United States.
Joseph W RedaPritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States.
Vlad NicolaescuDepartment of Microbiology, Howard T. Ricketts Laboratory, University of Chicago, Chicago, IL 60637, United States.
Kevin FurlongDepartment of Microbiology, Howard T. Ricketts Laboratory, University of Chicago, Chicago, IL 60637, United States.
Steve DvorkinDepartment of Microbiology, Howard T. Ricketts Laboratory, University of Chicago, Chicago, IL 60637, United States.
Shann S YuPritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States.
Balaji ManicassamyDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242, United States.
James L LaBelleDepartment of Pediatrics, University of Chicago Comer Children's Hospital, Chicago, IL 60637, United States.
Matthew V TirrellPritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States.
Glenn RandallDepartment of Microbiology, Howard T. Ricketts Laboratory, University of Chicago, Chicago, IL 60637, United States.
Marcin KwissaDepartment of Microbiology, Howard T. Ricketts Laboratory, University of Chicago, Chicago, IL 60637, United States.
Melody A SwartzPritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States.
Jeffrey A HubbellPritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States.
University of Chicago · USArgonne National Laboratory · USComer Children's Hospital · USUniversity of Iowa · US

Funding

VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI MARK W. LINGEN · 1985 to 2026
$122.1M
MEDICAL SCIENTIST TRAININGT32GM007281 · NIGMS · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 1985 to 2022
$32.1M
RESEARCH TRAINING IN RESPIRATORY BIOLOGYT32HL007605 · NHLBI · UNIVERSITY OF CHICAGO · PI Yun Fang, Gokhan M. Mutlu · 1985 to 2026
$18.1M
INTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007090 · NIAID · UNIVERSITY OF CHICAGO · PI Peter Aidan Savage · 1985 to 2026
$11.7M
Probing cellular, molecular and biomechanical barriers to immunotherapy in the tumor microenvironment with organotypic in vitro models of the tumor-lympho-immune interfaceR01CA253248 · NCI · UNIVERSITY OF CHICAGO · PI SWARTZ, MELODY ANN · 2021 to 2025
$2.8M
Paradoxical roles of tumor lymphangiogenesis on tumor immunity and implications for immunotherapy - Resubmission 01R01CA219304 · NCI · UNIVERSITY OF CHICAGO · PI SWARTZ, MELODY ANN · 2018 to 2022
$1.8M
A Potent and Specific Approach to Targeting B-Cell Lymphoma: Disrupting Malignant Protein-Protein Interactions Using CD19-Targeted Stapled Peptide Amphiphile NanoparticlesF30CA221250 · NCI · UNIVERSITY OF CHICAGO · PI SCHNORENBERG, MATHEW RYAN · 2017 to 2021
$250k
NCI NIH HHS F30 CA221250NCI NIH HHS P30 CA014599NCI NIH HHS R01 CA219304NCI NIH HHS R01 CA253248NHLBI NIH HHS T32 HL007605NIAID NIH HHS HHSN272201400008CNIAID NIH HHS T32 AI007090NIGMS NIH HHS T32 GM007281
6 · The paper itself

Abstract

A diverse portfolio of SARS-CoV-2 vaccine candidates is needed to combat the evolving COVID-19 pandemic. Here, we developed a subunit nanovaccine by conjugating SARS-CoV-2 Spike protein receptor binding domain (RBD) to the surface of oxidation-sensitive polymersomes. We evaluated the humoral and cellular responses of mice immunized with these surface-decorated polymersomes (RBD

Identifiers

PMID33851166
PMCPMC8043456
OpenAlexW3149020314

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.