Evidence map›Paper›PMID 33851073›Full record

ArticleNorthern clinics of Istanbul2021

Investigation of double-carbapenem efficiency in experimental sepsis of colistin-resistant

Imran Kosar, Gokcen Dinc, Esma Eren, Yusuf Aykemat, Mesut Kilic, Huseyin Kilic, Mehmet Doganay

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Northern clinics of Istanbul, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Global Prevalence of Colistin Resistance inPathogens (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Imran KosarDepartment of Medical Microbiology, Erciyes University Faculty of Medicine, Kayseri, Turkey.
Gokcen DincDepartment of Medical Microbiology, Erciyes University Faculty of Medicine, Kayseri, Turkey.
Esma ErenDepartment of Infectious Diseases and Clinical Microbiology, Erciyes University Faculty of Medicine, Kayseri, Turkey.
Yusuf AykematFaculty of Health Science, Nuh Naci Yazgan University, Kayseri, Turkey.
Mesut KilicDepartment of Internal Medicine, Kayseri City Hospital, Kayseri, Turkey.
Huseyin KilicDepartment of Medical Microbiology, Erciyes University Faculty of Medicine, Kayseri, Turkey.
Mehmet DoganayDepartment of Infectious Diseases and Clinical Microbiology, Lokman Hekim University Faculty of Medicine, Ankara, Turkey.
Erciyes University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objective

methodsIn the study, 8-10-week-old Balb-c mice were divided as control groups (positive and negative) and treatment groups (colistin, ertapenem+meropenem, and ertapenem+meropenem+colistin). Sepsis was developed in mice by an intraperitoneal injection of colistin resistant

resultsWhen the quantitative bacterial loads in the lung and liver tissues are evaluated, no statistically significant difference was observed between different antibiotic treatments (p>0.05). All three treatment options were not effective, especially in 24 h. Only the decrease in bacterial load at the 48

conclusionIn the light of these data, it was understood that double-carbapenem application was not sufficient in the treatment of experimental sepsis in mice with colistin-resistant

Indexed as

Colistin resistanceexperimental sepsisKlebsiella pneumoniae

Identifiers

PMID33851073
PMCPMC8039106
OpenAlexW3093930687

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.