ArticleAdvances in radiation oncology
Introducing Computed Tomography Simulation-Free and Electronic Patient-Reported Outcomes-Monitored Palliative Radiation Therapy into Routine Care: Clinical Outcomes and Implementation Experience.
Article in Advances in radiation oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Advanced Techniques for Single-fraction Palliative Radiotherapy Versus Standard Single Fraction Radiation
A Prospective Pilot Clinical Trial of Simulation-Free Celiac Plexus Pain Ablation Using Stereotactic Body Radiotherapy in Patients With Cancer-Related Celiac Pain
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Implementing patient-centred outcome measures in palliative care clinical practice. An updated systematic review of facilitators and barriers.BMC palliative care · 2026Pooled it
- Prospective feasibility study of diagnostic CT-based simulation-free palliative radiotherapy.Journal of radiation research · 2026Trial
- Development of a cost-effective end-to-end commissioning test for simulation-omitted direct-to-unit adaptive radiotherapy.Physics and imaging in radiation oncology · 2026Article
- Streamlining Paediatric Palliative Radiotherapy: A Case Study on Reducing Procedural Burden and Avoiding General Anaesthesia Using a Simulation-Free Radiotherapy (SF-RT) Protocol.Journal of medical radiation sciences · 2026Article
- Adaptation of digital integration of PROMs and PREMs in oncology during implementation: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Simulation-free palliative radiotherapy using diagnostic CT scans- is less more? A systematic review.Clinical and translational radiation oncology · 2026Review
- Simulation-Free Palliative Radiation Therapy: Implementing the Value-Based and Easier-Access Model of Care in a Rural Setting.Journal of medical radiation sciences · 2025Review
- Simulation-free cone beam CT-based online adaptive radiotherapy for metastatic spinal cord compression.Acta oncologica (Stockholm, Sweden) · 2025Article
- Adaptive-driven CT simulation-free multi-fraction SBRT radiotherapy: Initial clinical experience.Journal of applied clinical medical physics · 2025Article
- Article
- Development of an automated CBCT-based simulation-free platform for expedited palliative radiotherapy on a conventional linear accelerator.Journal of applied clinical medical physics · 2025Article
- Cardiac substructure delineation in radiation therapy - A state-of-the-art review.Journal of medical imaging and radiation oncology · 2024Review
- Palliative radiotherapy of soft tissue tumoral masses based on diagnostic instead of planning computed tomography scans.Physics and imaging in radiation oncology · 2024Article
- Simulation-free magnetic resonance-guided radiation therapy of prostate cancer.Physics and imaging in radiation oncology · 2024Article
- Feasibility of simulation free abdominal stereotactic adaptive radiotherapy using an expedited pre-plan workflow.Physics and imaging in radiation oncology · 2024Article
- Prompt Pain Relief From Bone Metastases: The Virtual Simulation Program.Advances in radiation oncology · 2024Article
- Article
- Evaluation of the clinical feasibility of cone-beam computed tomography guided online adaption for simulation-free palliative radiotherapy.Physics and imaging in radiation oncology · 2023Article
- Real-World Use of Electronic Patient-Reported Outcome (ePRO) Tools Integrated in the Electronic Medical Record During Radiation Therapy for Head and Neck Cancer: Feasibility Study.The Permanente journal · 2023Article
- Palliative intensity modulated radiotherapy of bone metastases based on diagnostic instead of planning computed tomography scans.Physics and imaging in radiation oncology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeOur purpose was to report outcomes of a novel palliative radiation therapy protocol that omits computed tomography simulation and prospectively collects electronic patient-reported outcomes (ePROs). METHODS AND MATERIALS: Patients receiving extracranial, nonstereotactic, linear accelerator-based palliative radiation therapy who met inclusion criteria (no mask-based immobilization and a diagnostic computed tomography within 4 weeks) were eligible. Global pain was scored with the 11-point numerical pain rating scale (NPRS). Patients were coded as having osseous or soft tissue metastases and no/mild versus severe baseline pain (NPRS ≥ 5). Pain response at 4 weeks was measured according to the international consensus (no analgesia adjustment). Transition to ePRO questionnaires was completed in 3 phases. Initially, pain assessments were collected on paper for 11 months, then pilot ePROs for 1 month and then, after adjustments, revised ePROs from 1 year onwards. ePRO feasibility criteria were established with reference to the paper-based process and published evidence.
resultsBetween May 2018 and November 2019, 542 consecutive patients were screened, of whom 163 were eligible (30%), and 160 patients were successfully treated. The proportion of patients eligible for the study improved from approximately 20% to 50% by study end. Routine care pain monitoring via ePROs was feasible. One hundred twenty-seven patients had a baseline NPRS recording. Ninety-five patients had osseous (61% severe pain) and 32 had soft tissue (25% severe pain) metastases. Eighty-four patients (66%) were assessable for pain response at 4 weeks. In the 41 patients with severe osseous pain, overall and complete pain response was 78% and 22%, respectively.
conclusionsBy study completion, 50% of patients receiving palliative extracranial radiation therapy avoided simulation, streamlining the treatment process and maximizing patient convenience. Pain response for patients with severe pain from osseous lesions was equivalent to published evidence.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.