ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2021
Frontotemporal dementia subtypes based on behavioral inhibition deficits.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03272230 (Assessment of Apathy in a Real-life Situation, With a Video and Sensors-based System in Healthy Subject and Patient With Cerebral Disease), which is not on this map. Cited by 10 papers.
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Assessment of Apathy in a Real-life Situation, With a Video and Sensors-based System in Healthy Subject and Patient With Cerebral Disease
Who cites it
10 citing papers in PubMed.
- A rostral prefrontal mediolateral gradient predicts creativity in frontotemporal dementia.Brain : a journal of neurology · 2026Article
- Molecular and statistical weaknesses of the p-tau217/AβJournal of molecular medicine (Berlin, Germany) · 2026Review
- Mapping the brain atrophy mediating increased impatience for reward in frontotemporal dementia.Communications biology · 2026Article
- Prevalence, treatment, and neural correlates of apathy in different forms of dementia: a narrative review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Review
- Behavioral disinhibition in stroke.Frontiers in neurology · 2024Article
- Deciphering the clinico-radiological heterogeneity of dysexecutive Alzheimer's disease.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Multidimensional inhibitory signatures of sentential negation in behavioral variant frontotemporal dementia.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Functional connectivity correlates of reduced goal-directed behaviors in behavioural variant frontotemporal dementia.Brain structure & function · 2022Article
- Disentangling Clinical Profiles of Apathy in Behavioral Variant Frontotemporal Dementia.Journal of Alzheimer's disease : JAD · 2022Article
- Frontotemporal dementia subtypes based on behavioral inhibition deficits.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
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17 authors.
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Abstract
introductionWe aimed to investigate phenotypic heterogeneity in the behavioral variant of frontotemporal dementia (bvFTD) through assessment of inhibition deficits.
methodsWe assessed occurrences of 16 behavioral inhibition deficits from video recordings of 15 bvFTD patients (early stage) and 15 healthy controls (HC) in an ecological setting. We extracted dimensions of inhibition deficit and analyzed their correlations with cognitive and clinical measures. Using these dimensions, we isolated patient clusters whose atrophy patterns were explored.
resultsAfter identifying two patterns of inhibition deficit (compulsive automatic behaviors and socially unconventional behaviors), we isolated three behavioral clusters with distinct atrophy patterns. BvFTD-G0 (N = 3), an outlier group, showed severe behavioral disturbances and more severe ventromedial prefrontal cortex/orbitofrontal cortex atrophy. Compared to bvFTD-G1 (N = 6), bvFTD-G2 (N = 6) presented higher anxiety and depression along with less diffuse atrophy especially in midline regions. DISCUSSION: Identifying clinico-anatomical profiles through behavior observation could help to stratify bvFTD patients for adapted treatments.
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