Evidence map›Paper›PMID 33850939›Full record

ArticleIranian journal of biotechnology2020

An Integrative

Mehri Azadi, Fatemeh Alemi, Sedigheh Sadeghi, Maryam Mohammadi, Nowrooz Ali Rahimi, Sako Mirzaie, Farideh Vahabi, Shirin Parvaz, Mohammad Arjmand, Zahra Zamani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Iranian journal of biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mehri AzadiBiochemistry Department, Pasteur Institute of Iran, Tehran, Iran.
Fatemeh AlemiChemical Engineering Department, Islamic Azad University, Tehran, Iran.
Sedigheh SadeghiBiochemistry Department, Pasteur Institute of Iran, Tehran, Iran.
Maryam MohammadiBiochemistry Department, Pasteur Institute of Iran, Tehran, Iran.
Nowrooz Ali RahimiBiochemistry Department, Pasteur Institute of Iran, Tehran, Iran.
Sako MirzaieBiology Department, Islamic Azad University, Pasdaran Avenue, Sanandaj, Iran.
Farideh VahabiBiochemistry Department, Pasteur Institute of Iran, Tehran, Iran.
Shirin ParvazBiochemistry Department, Pasteur Institute of Iran, Tehran, Iran.
Mohammad ArjmandBiochemistry Department, Pasteur Institute of Iran, Tehran, Iran.
Zahra ZamaniBiochemistry Department, Pasteur Institute of Iran, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundClove oil is known for its medicinal properties. The mechanism of anti-cancer properties of

objectivesAn integrative analysis correlated the metabolites identified by MATERIALS AND

methodsRaji cells treated with clove oil were collected and sent for

results50% inhibitory concentration of clove oil was 50 µg/ml and the model anticipated 74 genes with differentiating metabolites being some amino acids, cholesterol and fucose.

conclusionThe integrative study predicted that the anti cancer mechanism of clove oil involves novel enzymes, as likely drug targets, 24-dehydrocholesterol reductase and 7-dehydrocholesterol reductase in cholesterol biosynthesis, dehydrofolate reductase in one carbon metabolism and serine palmitoyl-transferase long chain in sphingolipid biosynthesis.

Indexed as

Genes and pathwaysIn Silico mathematical modelMethanol clove extractRaji cells

Identifiers

PMID33850939
PMCPMC8035415

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.