Evidence map›Paper›PMID 33850810›Full record

ArticleTranslational pediatrics2021

Proteomic analysis of urine reveals biomarkers for the diagnosis and phenotyping of abdominal-type Henoch-Schonlein purpura.

Lulu Jia, Jianqiang Wu, Jing Wei, Lina Du, Panpan Wang, Yanju Zhang, Yuncui Yu, Xiaoling Wang, Yan Yang, Youhe Gao

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PubMed Full text at PMC Publisher
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Article in Translational pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

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0cells of the map it votes in
6citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Lulu JiaClinical Research Center, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Jianqiang WuMedical Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Jing WeiDepartment of Biochemistry and Molecular Biology, School of Life Sciences, Beijing Normal University, Gene Engineering Drug and Biotechnology Beijing Key Laboratory, Beijing, China.
Lina DuDepartment of Chinese Medicine, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Panpan WangDepartment of Chinese Medicine, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Yanju ZhangClinical Research Center, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Yuncui YuClinical Research Center, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Xiaoling WangClinical Research Center, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Yan YangDepartment of Chinese Medicine, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Youhe GaoDepartment of Biochemistry and Molecular Biology, School of Life Sciences, Beijing Normal University, Gene Engineering Drug and Biotechnology Beijing Key Laboratory, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAbdominal-type Henoch-Schonlein purpura (HSP) is a common refractory disease in children. Currently, no specific diagnostic biomarker is available for HSP.

methodsChildren with abdominal type HSP were first diagnosed with three syndromes using Chinese traditional medicine. The urinary proteomes among the three syndromes of patients with abdominal type HSP and healthy controls were compared using two label-free proteomics quantifications, including data-dependent acquisition and data-independent acquisition.

resultsFor the comparison between patients with abdominal type HSP and healthy children, a total of 75 differential urinary proteins were identified by determining the overlap of the two experiments. The ingenuity pathway analysis (IPA) analysis showed that these differential proteins were correlated with the pathogenesis of abdominal type HSP. Of these, 37 proteins were distributed in 13 solid tissues as tissue-enriched proteins. Monitoring changes in these proteins might help us detect uncommon clinical manifestations of HSP. Patients with abdominal type HSP can be further distinguished into three syndromes based on the urine proteome. Finally, a panel of six urinary proteins (P25774, P09417, Q7Z5L0, P60900, P14550 and P09668) was constructed for both the diagnosis and phenotyping of abdominal type HSP.

conclusionsUrinary protein biomarkers for the diagnosis and phenotyping of abdominal type HSP were identified, which will contribute to the personalized treatment of patients with abdominal type HSP.

Indexed as

biomarkersHenoch-Schonlein purpura (HSP)precision treatmentproteomicsurine

Identifiers

PMID33850810
PMCPMC8039785

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