Evidence map›Paper›PMID 33850779›Full record

ReviewTranslational andrology and urology2021

Histology and sperm retrieval among men with Y chromosome microdeletions.

Wallace Yuen, Andrew P Golin, Ryan Flannigan, Peter N Schlegel

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Translational andrology and urology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Review
  4. Article
  5. Review
  6. Sperm retrieval, fertilization rates, and clinical outcomes of infertile men with Y chromosome microdeletion A retrospective cohort study.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. 2023 Canadian Urological Association guideline: Evaluation and management of azoospermia.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2023
    Article
  13. Gene Polymorphism, Microdeletion, and Gene Expression ofReports of biochemistry & molecular biology · 2023
    Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Wallace YuenDepartment of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.
Andrew P GolinDepartment of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.
Ryan FlanniganDepartment of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.
Peter N SchlegelDepartment of Urology, Weill Cornell Medicine, New York, NY, USA.
University of British Columbia · CAWeill Cornell Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this review of Y chromosome microdeletions, azoospermia factor (AZF) deletion subtypes, histological features and microTESE sperm retrieval rates are summarized after a systematic literature review. PubMed was searched and papers were identified using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Approximately half of infertile couples have a male factor contributing to their infertility. One of the most common genetic etiologies are Y chromosome microdeletions. Men with Y chromosome microdeletions may have rare sperm available in the ejaculate or undergo surgical sperm retrieval and subsequent intracytoplasmic sperm injection to produce offspring. Azoospermia or severe oligozoospermia are the most common semen analysis findings found in men with Y chromosome microdeletions, associated with impaired spermatogenesis. Men with complete deletions of azoospermia factor a, b, or a combination of any loci have severely impaired spermatogenesis and are nearly always azoospermic with no sperm retrievable from the testis. Deletions of the azoospermia factor c or d often have sperm production and the highest likelihood of a successful sperm retrieval. In men with AZFc deletions, histologically, 46% of men demonstrate Sertoli cell only syndrome on biopsy, whereas 38.2% have maturation arrest and 15.7% have hypospermatogenesis. The microTESE sperm retrieval rates in AZFc-deleted men range from 13-100% based on the 32 studies analyzed, with a mean sperm retrieval rate of 47%.

Indexed as

azoospermiaazoospermia factormale infertilitymicroTESEsperm retrievaltestis biopsyY chromosome microdeletion

Identifiers

PMID33850779
PMCPMC8039602
OpenAlexW3028297068

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.