ArticleMetabolic engineering communications2021
Analysis of metabolic network disruption in engineered microbial hosts due to enzyme promiscuity.
Article in Metabolic engineering communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
10 citing papers in PubMed.
- Biphasic Metabolic Control of Shikimic Acid Production inACS omega · 2026Article
- Enzyme promiscuity in the field of synthetic biology applied to white biotechnology: Opportunities and weaknesses.Biodesign research · 2025Review
- A new paradigm for the regulation of A40926B0 biosynthesis.Synthetic and systems biotechnology · 2025Article
- Merging the computational design of chimeric type I polyketide synthases with enzymatic pathways for chemical biosynthesis.Nature communications · 2025Article
- Development of a Multienzyme Cascade for Salvianolic Acid A Synthesis from l-Tyrosine.ACS omega · 2025Article
- Pickaxe: a Python library for the prediction of novel metabolic reactions.BMC bioinformatics · 2023Article
- Using graph neural networks for site-of-metabolism prediction and its applications to ranking promiscuous enzymatic products.Bioinformatics (Oxford, England) · 2023Article
- Boost-RS: boosted embeddings for recommender systems and its application to enzyme-substrate interaction prediction.Bioinformatics (Oxford, England) · 2022Article
- Microbial containment device: A platform for comprehensive analysis of microbial metabolism without sample preparation.Frontiers in microbiology · 2022Article
- Approaches for completing metabolic networks through metabolite damage and repair discovery.Current opinion in systems biology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Increasing understanding of metabolic and regulatory networks underlying microbial physiology has enabled creation of progressively more complex synthetic biological systems for biochemical, biomedical, agricultural, and environmental applications. However, despite best efforts, confounding phenotypes still emerge from unforeseen interplay between biological parts, and the design of robust and modular biological systems remains elusive. Such interactions are difficult to predict when designing synthetic systems and may manifest during experimental testing as inefficiencies that need to be overcome. Transforming organisms such as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.