Evidence map›Paper›PMID 33850456›Full record

ArticleReproductive medicine and biology2021

The prevalence of celiac disease in women with infertility-A systematic review with meta-analysis.

Ida Glimberg, Linnea Haggård, Benjamin Lebwohl, Peter H R Green, Jonas F Ludvigsson

Open access · goldAbstract read
In one paragraph

Article in Reproductive medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Observational
  6. Coeliac disease: complications and comorbidities.Nature reviews. Gastroenterology & hepatology · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Who to screen and how to screen for celiac disease.World journal of gastroenterology · 2022
    Review
  14. Review article: Systemic consequences of coeliac disease.Alimentary pharmacology & therapeutics · 2022
    Review
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Ida GlimbergSchool of Medical Sciences Örebro University Örebro Sweden.
Linnea HaggårdDepartment of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden.
Benjamin LebwohlCeliac Disease Center Department of Medicine Columbia University College of Physicians and Surgeons New York NY USA.
Peter H R GreenCeliac Disease Center Department of Medicine Columbia University College of Physicians and Surgeons New York NY USA.
Jonas F LudvigssonDepartment of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden.ORCID https://orcid.org/0000-0003-1024-5602
Columbia University · USKarolinska Institutet · SEÖrebro University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine the prevalence of celiac disease in infertile women.

methodsA systematic search of four databases was conducted up until February 6, 2020. The search terms "c(o)eliac disease", "gluten", "vill(o)us atrophy", "infertility" and "subfertility" yielded 1142 unique hits. Articles in other languages than English, conference abstracts, letters, and publications where relevant information was missing were excluded. In our main analysis, celiac disease had to be verified by duodenal biopsy. The titles and abstracts, and the full-text articles were independently reviewed by two researchers. A fixed-effect model was used to calculate the weighted prevalence.

resultsBased on 11 studies (1617 women), the pooled prevalence of biopsy-confirmed celiac disease was 0.7% (95% CI = 0.2%-1.2%) in women with any infertility. Restricting our study population to women with

conclusionOur results indicate that celiac disease is not more common in infertile women than in the general population. Celiac screening in infertile women may have low yield.

Indexed as

celiac diseasefemale infertilitygynecologic diseasemeta‐analysisprevalence

Identifiers

PMID33850456
PMCPMC8022102
OpenAlexW3136165499

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.