ArticleReproductive medicine and biology2021
The effect of repeated cryopreservation and thawing using cryotip on the clinical outcomes of embryos.
Article in Reproductive medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Does double cryopreservation as well as double biopsy affect embryo viability and clinical outcomes? Evidence from a systematic review of the literature.Journal of assisted reproduction and genetics · 2025Pooled it
- Embryonic and neonatal outcomes following double vitrification/thawing: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2025Pooled it
- Repeated cryopreservation is associated with poor pregnancy outcomes after frozen-thawed embryo transfer in women aged < 35 years: a propensity-score matched cohort study.European journal of medical research · 2025Article
- Article
- Effect of repeated vitrification of human embryos on pregnancy and neonatal outcomes.Journal of ovarian research · 2024Article
- Smooth endoplasmic reticulum cluster presence does not affect embryo ploidy.Archives of gynecology and obstetrics · 2023Article
- The effect of repeated cryopreservation and thawing using cryotip on the clinical outcomes of embryos.Reproductive medicine and biology · 2021Article
- The effects of differences in trophectoderm biopsy techniques and the number of cells collected for biopsy on next-generation sequencing results.Reproductive medicine and biologyArticle
- A novel trophectoderm biopsy technique for all blastocyst stages.Reproductive medicine and biologyArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare the clinical outcomes of embryo transfers that were cryopreserved and thawed two or three times with those cryopreserved and thawed once by CryoTip.
methodsData for 388 single cryopreserved-thawed blastocyst transfer cycles, performed from April 2012 to March 2014, were assessed. The blastocysts were classified into three groups: blastocysts (A) cryopreserved once, (B) cryopreserved twice, and (C) cryopreserved three times.
resultsThe pregnancy rate was 43.8% (134/306) in group A and 46.3% (38/82) in group B, while the miscarriage rate was 29.1% (39/134) in group A and 23.7% (9/38) in group B. The rate of improvement/maintenance of blastocyst grade was 84.0% (257/306) in group A and 80.5% (66/82) in group B. The pregnancy and miscarriage rates of the blastocysts that showed improvement/maintenance in the grade were 45.9% (118/257) and 29.7% (35/118) in group A and 48.5% (32/66) and 21.9% (7/32) in group B, respectively. The pregnancy rate was 33.3% (2/6), while the miscarriage rate was 0.0% (0/2) in group C.
conclusionsPregnancy rates achieved with re-cryopreserved and rethawed blastocyst transfer were comparable to those achieved with single cryopreserved-thawed blastocyst transfer.
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