Evidence map›Paper›PMID 33850171›Full record

ArticleScientific reports2021

Multi-modal nonlinear optical and thermal imaging platform for label-free characterization of biological tissue.

Wilson R Adams, Brian Mehl, Eric Lieser, Manqing Wang, Shane Patton, Graham A Throckmorton, J Logan Jenkins, Jeremy B Ford, Rekha Gautam, Jeff Brooker and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Targeting 5-HTCirculation · 2021
    Article
  13. Advances in stimulated Raman scattering imaging for tissues and animals.Quantitative imaging in medicine and surgery · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Wilson R AdamsDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
Brian MehlThorlabs Imaging Research, Sterling, VA, USA.
Eric LieserThorlabs Imaging Research, Sterling, VA, USA.
Manqing WangCollege of Bioengineering, Chongqing University, Chongqing, China.
Shane PattonThorlabs Imaging Research, Sterling, VA, USA.
Graham A ThrockmortonDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
J Logan JenkinsDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
Jeremy B FordDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
Rekha GautamDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
Jeff BrookerThorlabs Imaging Research, Sterling, VA, USA.
E Duco JansenDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
Anita Mahadevan-JansenDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA. anita.mahadevan-jansen@vanderbilt.edu.
Vanderbilt University · USThorlabs (United States) · USChongqing University · CNVanderbilt University Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ability to characterize the combined structural, functional, and thermal properties of biophysically dynamic samples is needed to address critical questions related to tissue structure, physiological dynamics, and disease progression. Towards this, we have developed an imaging platform that enables multiple nonlinear imaging modalities to be combined with thermal imaging on a common sample. Here we demonstrate label-free multimodal imaging of live cells, excised tissues, and live rodent brain models. While potential applications of this technology are wide-ranging, we expect it to be especially useful in addressing biomedical research questions aimed at the biomolecular and biophysical properties of tissue and their physiology.

Indexed as

BrainAnimalsHumansMiceMultimodal ImagingOptical ImagingRats

Identifiers

PMID33850171
PMCPMC8044215
OpenAlexW3154908559

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.