ArticleNature communications2021
Spreading depression as an innate antiseizure mechanism.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
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Who cites it
51 citing papers in PubMed, 83 citations in OpenAlex.
- Detection and Quantification of Spreading Depolarization in Drosophila melanogaster Using High-Throughput, Wide-Field Brain Imaging.Current protocols · 2026Article
- Local targeted suppression of neocortical spreading depolarization amplitude by viral expression of KCa3.1 channels.Gene therapy · 2026Article
- Multifocal Initiation of Spreading Depolarization by Generalized Tonic-Clonic Seizures.International journal of molecular sciences · 2026Article
- Whole brain fluorescence imaging iniScience · 2026Article
- Spreading depolarization: A wave that precedes and drives cerebral ischemic cell death-Target for neuroprotection.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- Dual role of spreading depolarization in an epileptic focus.Epilepsia · 2026Article
- Tsunamis hiding in plain sight: spreading depression in clinical neurology.Nature reviews. Neurology · 2026Review
- Review
- Interhemispheric Functional Hypoconnectivity Is an Early Marker of Cortical Epileptogenesis.Biomedicines · 2026Article
- Chemogenetic activation of hippocampal area CA2 promotes acute and chronic seizures in a mouse model of epilepsy.Neurobiology of disease · 2026Article
- Spreading depolarization is followed by seizure-like activation of the hippocampus: potential mechanism of migraine-aura triggered seizures.The journal of headache and pain · 2025Article
- Dendritic beading during early brain development impairs signal transmission and synaptic plasticity.Acta neuropathologica communications · 2025Article
- Olfactory Bulb Pinprick Induction of Cortical Spreading Depolarizations.bioRxiv : the preprint server for biology · 2025Article
- Alternating hemiplegia of childhood associated mutations in Atp1a3 reveal diverse neurological alterations in mice.Neurobiology of disease · 2025Article
- Inhibiting astrocyte calcium dynamics terminates status epilepticus via wireless septal stimulation.Scientific reports · 2025Article
- Rodent and human seizures demonstrate a dynamic interplay with spreading depolarizations.Neurobiology of disease · 2025Article
- Integrating endocannabinoid signaling, CCK interneurons, and hippocampal circuit dynamics in behaving animals.Neuron · 2025Review
- Electroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humans.Nature communications · 2025Article
- Characterization of spreading depolarizations in swine following superior sagittal sinus occlusion: a novel gyrencephalic model study.Thrombosis journal · 2025Article
- The link between spreading depolarization and innate immunity in the central nervous system.The journal of headache and pain · 2025Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Spreading depression (SD) is an intense and prolonged depolarization in the central nervous systems from insect to man. It is implicated in neurological disorders such as migraine and brain injury. Here, using an in vivo mouse model of focal neocortical seizures, we show that SD may be a fundamental defense against seizures. Seizures induced by topical 4-aminopyridine, penicillin or bicuculline, or systemic kainic acid, culminated in SDs at a variable rate. Greater seizure power and area of recruitment predicted SD. Once triggered, SD immediately suppressed the seizure. Optogenetic or KCl-induced SDs had similar antiseizure effect sustained for more than 30 min. Conversely, pharmacologically inhibiting SD occurrence during a focal seizure facilitated seizure generalization. Altogether, our data indicate that seizures trigger SD, which then terminates the seizure and prevents its generalization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.