Evidence map›Paper›PMID 33849973›Full record

ArticlemBio2021

Enterovirus 2A

Jonathan P Kastan, Martine W Tremblay, Michael C Brown, Joseph D Trimarco, Elena Y Dobrikova, Mikhail I Dobrikov, Matthias Gromeier

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
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  4. Polio virotherapy provokes MDA5 signaling and CD4Microbiology and molecular biology reviews : MMBR · 2025
    Review
  5. Functions of Tomato (International journal of molecular sciences · 2025
    Article
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  7. Coxsackievirus B3-Induced mMicroorganisms · 2024
    Article
  8. Recent insights into NCurrent opinion in genetics & development · 2024
    Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. mFrontiers in cellular and infection microbiology · 2023
    Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jonathan P KastanDepartment of Neurosurgery, Duke University Medical Center, Durham, North Carolina, USA.ORCID 0000-0001-6454-825X
Martine W TremblayUniversity Program in Genetics and Genomics, Duke University Medical Center, Durham, North Carolina, USA.
Michael C BrownDepartment of Neurosurgery, Duke University Medical Center, Durham, North Carolina, USA.
Joseph D TrimarcoMolecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA.
Elena Y DobrikovaDepartment of Neurosurgery, Duke University Medical Center, Durham, North Carolina, USA.
Mikhail I DobrikovDepartment of Neurosurgery, Duke University Medical Center, Durham, North Carolina, USA.
Matthias GromeierDepartment of Neurosurgery, Duke University Medical Center, Durham, North Carolina, USA grome001@mc.duke.edu.ORCID 0000-0003-4538-0302
Duke Medical Center · USDuke University · US

Funding

Innate Antiviral Signals for Cancer ImmunotherapyR01NS108773 · NINDS · DUKE UNIVERSITY · PI Matthias Gromeier, Smita K. Nair · 2018 to 2026
$3.3M
Genetics and Genomics Training GrantT32GM136627 · NIGMS · DUKE UNIVERSITY · PI ALLISON E ASHLEY-KOCH · 2020 to 2026
$3.1M
Cancer Immunotherapy Through Intratumoral Activation of Recall ResponsesF32CA224593 · NCI · DUKE UNIVERSITY · PI BROWN, MICHAEL CLAVON · 2018 to 2020
$187k
NCI NIH HHS F32 CA224593NIGMS NIH HHS T32 GM136627NINDS NIH HHS R01 NS108773
6 · The paper itself

Abstract

Enteroviruses (EV) deploy two proteases that mediate viral polyprotein cleavage and host cell manipulation. Here, we report that EV 2A proteases cleave all three members of the YTHDF protein family, cytosolic

Indexed as

Cell LineEnterovirusHeLa CellsHumansImmunity, InnateInterferon Type IJanus KinasesProteolysisRNA-Binding ProteinsSignal TransductionSTAT Transcription FactorsViral ProteinsInterferon Type IJanus KinasesRNA-Binding ProteinsSTAT Transcription FactorsViral ProteinsYTHDF3 protein, human2A proteaseenterovirusinnate immunityinterferon stimulated geneJak/Stat signalingm6A modificationpoliovirustype III interferontype I interferonYTHDF proteins

Identifiers

PMID33849973
PMCPMC8092205
OpenAlexW3154579133

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.