ArticleBMJ open2021
Symptom burden in multimorbidity: a population-based combined questionnaire and registry study from Denmark.
Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Interpreting higher-order dependence in multimorbidity using cohort data: A partial information decomposition approach.PLoS computational biology · 2026Article
- Medication Experience and Associated Factors in Older Adults with Multiple Chronic Conditions in Rural Henan Province, China: A Single-Center Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- Developmental trauma in functional motor disorder: the mediating roles of affective symptoms and multimorbidity.Psychological medicine · 2026Article
- Chronic disease multimorbidity and mental health among older adults in China: The moderating roles of family and social support.PloS one · 2026Article
- The role of general practice in the identification of age-related vision impairment and chronic eye diseases: a systematic review.BJGP open · 2025Article
- Development and psychometric testing of symptom severity scale in older patients with cardiometabolic multimorbidity.BMC geriatrics · 2025Article
- Exploring the relationship between education and academic ability in childhood with healthcare utilization in adulthood: findings from the Aberdeen Children of the 1950s (ACONF).European journal of public health · 2025Article
- Social participation and insomnia in Chinese older adults with multimorbidity: mediating roles of frailty, anxiety, and depression.BMC geriatrics · 2025Article
- Multimorbidity Is Associated With Symptom Severity and Disease Progression in Patients with Paroxysmal Atrial Fibrillation-Data From the RACE V Study.Journal of the American Heart Association · 2025Article
- Symptom representations in people with multimorbidity undergoing treatment for cancer: a qualitative descriptive study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- 'Stuck or unstable' - partnerships between GPs and patients with complex chronic conditions: A qualitative study.BJGP open · 2025Article
- The impact of living with multiple long-term conditions (multimorbidity) on everyday life - a qualitative evidence synthesis.BMC public health · 2024Article
- Social determinants of health and emergency department visits among older adults with multimorbidity: insight from 2010 to 2018 National Health Interview Survey.BMC public health · 2024Article
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- Chronic disease and multimorbidity in the Chinese older adults' population and their impact on daily living ability: a cross-sectional study of the Chinese Longitudinal Healthy Longevity Survey (CLHLS).Archives of public health = Archives belges de sante publique · 2024Article
- Interventions Addressing Symptoms in Older Adults with Multimorbidity: An Umbrella Review.Journal of multidisciplinary healthcare · 2024Review
- Multimorbidity in the Elderly: A Systematic Bibliometric Analysis of Research Output.International journal of environmental research and public health · 2021Review
- Engagement with consumer smartwatches for tracking symptoms of individuals living with multiple long-term conditions (multimorbidity): A longitudinal observational study.Journal of multimorbidity and comorbidityArticle
- Prevalence of multimorbidity during 18 years in Denmark. A nationwide register study.Journal of multimorbidity and comorbidityArticle
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePatients with multimorbidity may carry a large symptom burden. Symptoms are often what drive patients to seek healthcare and they also assist doctors with diagnosis. We examined whether symptom burden is additive in people with multimorbidity compared with people with a single morbidity.
designThis is a longitudinal cohort study drawing on questionnaire and Danish national registry data. Multimorbidity was defined as having diagnoses from at least two out of ten morbidity groups. Associations between morbidity groups and symptom burden were estimated with multivariable models.
participantsIn 2012, 47 452 participants from the Danish Symptom Cohort answered a questionnaire about symptoms (36 symptoms in total), including whether symptoms were affecting their daily activities (
main outcome measureThe primary outcome was symptom burden.
resultsParticipants without morbidity reported 4.77 symptoms (out of 36 possible). Participants with one, two or three morbidities reported more symptoms than patients without morbidity (0.95 (CI 0.86 to 1.03), 1.87 (CI 1.73 to 2.01) and 2.89 (CI 2.66 to 3.12), respectively). Furthermore, they reported a higher impairment score (0.36 (0.32 to 0.39), 0.65 (0.60 to 0.70) and 1.06 (0.98 to 1.14)) and a higher worry score (0.34 (0.31 to 0.37), 0.62 (0.57 to 0.66) and 1.02 (0.94 to 1.10)) than participants without morbidity. In 45 possible combinations of multimorbidity (participants with two morbidities), interaction effects were additive in 37, 41 and 36 combinations for the number of symptoms, impairment score and worry score, respectively.
conclusionParticipants without morbidity reported a substantial number of symptoms. Having a single morbidity or multimorbidity resulted in approximately one extra symptom for each extra morbidity. In most combinations of multimorbidity, symptom burden was additive.
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