ArticleBiomaterials research2021
Correlation between two-dimensional micro-CT and histomorphometry for assessment of the implant osseointegration in rabbit tibia model.
Article in Biomaterials research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Effect of chitosan/inorganic nanomaterial scaffolds on bone regeneration and related influencing factors in animal models: A systematic review.Frontiers in bioengineering and biotechnology · 2022Pooled it
- Rat Calvarial Defect Models in Bone Regeneration Research: A Narrative Review of Critical Size and Micro-Computed Tomography Outcome Reporting.Animals : an open access journal from MDPI · 2026Review
- Comparative Evaluation of Bovine- and Porcine-Derived Xenografts in Rabbit Calvarial and Canine Mandibular Dehiscence Models.Dentistry journal · 2026Article
- Bone Morphogenetic Protein (BMP) 9 Outperforms BMP2 in Osteogenesis and Osseointegration: In Vitro and In Vivo.Clinical implant dentistry and related research · 2026Article
- In Vitro and In Vivo Evaluation of Yttria-Niobia-Stabilized Zirconia Sandblasted Surface at Bone-Implant Interface with 3-Dimensional Visualization via Advanced Hard Tissue Clearing.Biomaterials research · 2026Article
- Early Osseointegration in a Sheep Tibia Model: Correlating Digital Periapical Radiograph Gray-Level and RGB-Derived Metrics with Histologic Tissue Composition.Journal of functional biomaterials · 2025Article
- The Anatomical Basis of Nonuniform Settlement of the C2 Lateral Mass and Its Association With Atlantoaxial Osteoarthritis.Orthopaedic surgery · 2025Article
- Effect of Ti6Al4V Alloy Surface and Porosity on Bone Osseointegration: In Vivo Pilot Study in Rabbits.Materials (Basel, Switzerland) · 2025Article
- Evaluation of trabecular bone microstructure and cortical morphology using cone-beam and micro-CT images: impact of tube voltage setting.BMC oral health · 2025Article
- Histomorphometric Analysis of Osseointegrated Intraosseous Dental Implants Using Undecalcified Specimens: A Scoping Review.Biomimetics (Basel, Switzerland) · 2024Article
- Ionizing radiation effects on osseointegration: a pre-clinical study.Brazilian oral research · 2024Article
- Polyetheretherketone implants with hierarchical porous structure for boosted osseointegration.Biomaterials research · 2023Article
- Effect of data binning and frame averaging for micro-CT image acquisition on the morphometric outcome of bone repair assessment.Scientific reports · 2022Article
- Bone Quantification Around Chitosan-Coated Titanium Dental Implants: A Preliminary Study by Micro-CT Analysis in Jaw of a Canine Model.Frontiers in bioengineering and biotechnology · 2022Article
- Biocompatibility Analyses of HF-Passivated Magnesium Screws for Guided Bone Regeneration (GBR).International journal of molecular sciences · 2021Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundHistology is considered as a gold standard for analyzing bone architecture. However, histomorphometry is a destructive method and only offers the bone information of a limited location. Micro-computed tomography (μCT) is a non-destructive technology and provides a slice at any site. The aim of this study was to compare the correlation of the Bone-to-Implant Contact ratio (BIC) between 2D micro-CT (μCT) and histomorphometry and to investigate a method for assessing the osseointegration of the implant by 2D μCT.
methodsA total of 18 implants were divided into three groups (6 implants per group), and inserted into the rabbit tibia defects as follow: implant only (Implant group), implant with β-TCP/hydrogel (TCP group), implant with rhBMP-2 loaded β-TCP/hydrogel composite (BMP-2 group). After 4 weeks of implantation, the specimens were collected to take the micro-CT scan with an aluminum filter and performed H&E staining on the undecalcified sections. The 2D μCT slices were chosen at an angle of 0°, 45°, 90° and 135° with the representative histological section to measure BIC. And the correlations between BICs of 2D μCT and BICs of histology were evaluated.
resultsIn each group, BICs at the same sites measured by histomorphometry and corresponding 2D μCT presented the same trend and shown no significant difference between the two methods (P > 0.05). BICs of histological sections and BICs of corresponding 2D μCT slices presented a strong correlation in the implant group (γ = 0.74, P = 0.09), a moderate correlation in the TCP group (γ = 0.46, P = 0.35), a weak correlation in the BMP-2 group (γ = 0.30, P = 0.56). In the implant group, the relationship between BIC-Mean-μCTs and BICs-Histology has presented a significant linear correlation (γ = 0.84, P = 0.04).
conclusionsIntegrating bone information of several 2D μCT slices in different sites to measure BIC is a feasible method for assessing the implant osseointegration.
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