Evidence map›Paper›PMID 33849532›Full record

ArticleBMC medical genomics2021

Identification of genes and pathways involved in malignant pleural mesothelioma using bioinformatics methods.

Xingsheng Liu, Kun Qian, Gaojun Lu, Peng Chen, Yi Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Xingsheng LiuDepartment of Thoracic Surgery, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing, 100053, China.
Kun QianDepartment of Thoracic Surgery, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing, 100053, China.
Gaojun LuDepartment of Thoracic Surgery, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing, 100053, China.
Peng ChenDepartment of Thoracic Surgery, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing, 100053, China.
Yi ZhangDepartment of Thoracic Surgery, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing, 100053, China. zhangyi@xwhosp.org.ORCID 0000-0001-7641-6350
Capital Medical University · CN

Funding

Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding SupporXingsheng Liu XMLX201702
6 · The paper itself

Abstract

backgroundMalignant pleural mesothelioma (MPM) is a rare tumor in the pleura. This study was carried out to identify key genes and pathways that may be involved in MPM.

methodsMicroarray datasets GSE51024 and GSE2549 were analyzed for differentially expressed genes (DEGs) between normal and MPM tissues. The identified DEGs were subjected to functional analyses using bioinformatics tools.

resultsA total of 276 DEGs were identified, consisting of 187 downregulated and 79 upregulated genes. Gene ontology and Kyoto encyclopedia of genes and genomes pathway enrichment analysis indicated that the DEGs were enriched in extracellular structure organization, extracellular matrix, and ECM-receptor interaction. Due to high degree of connectivity among 24 hub genes, EZH2 and HMMR are likely to play roles in the carcinogenesis and progression of MPM. The two genes were found over-expressed in MPM tissues. Patients with elevated EZH2 and HMMR expressions had poor overall survival.

conclusionsEZH2 and HMMR are identified to be the hub genes for MPM and they may be further characterized to better understand the molecular mechanisms underlying the carcinogenesis of MPM.

Indexed as

Computational BiologyGene Expression Regulation, NeoplasticLung NeoplasmsMesotheliomaMesothelioma, MalignantEnhancer of Zeste Homolog 2 ProteinGene Expression ProfilingGene OntologyGene Regulatory NetworksHumansPleural NeoplasmsEnhancer of Zeste Homolog 2 ProteinEZH2 protein, humanBioinformaticsCancerDifferentially expressed genesGene expression profileMicroarrayProtein–protein interaction

Identifiers

PMID33849532
PMCPMC8045401
OpenAlexW3155810756

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.