Evidence map›Paper›PMID 33849511›Full record

ArticleBMC oral health2021

Association between metabolic and hormonal profile, proinflammatory cytokines in saliva and gingival health in adolescent females with polycystic ovary syndrome.

Natalia Wendland, Justyna Opydo-Szymaczek, Dorota Formanowicz, Anna Blacha, Grażyna Jarząbek-Bielecka, Małgorzata Mizgier

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
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  4. Review
  5. Review
  6. [Polycystic ovary syndrome is positively correlated with periodontitis: a prospective study].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024
    Article
  7. Impact of Polycystic Ovary Syndrome on Periodontal Status of Women of Adolescent and Adult Age Groups: A Cross-Sectional Study.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2024
    Article
  8. Article
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  10. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Natalia WendlandChair and Department of Pediatric Dentistry, Poznan University of Medical Sciences, 70 Bukowska Street, 60-812, Poznan, Poland.
Justyna Opydo-SzymaczekChair and Department of Pediatric Dentistry, Poznan University of Medical Sciences, 70 Bukowska Street, 60-812, Poznan, Poland. jopydo@ump.edu.pl.ORCID 0000-0001-5091-3316
Dorota FormanowiczChair and Department of Medical Chemistry and Laboratory Medicine, Poznan University of Medical Sciences, 8 Rokietnicka Street, 60-806, Poznan, Poland.
Anna BlachaChair and Department of Medical Chemistry and Laboratory Medicine, Poznan University of Medical Sciences, 8 Rokietnicka Street, 60-806, Poznan, Poland.
Grażyna Jarząbek-BieleckaDepartment of Perinatology and Gynecology, Division of Developmental Gynecology and Sexology, Poznan University of Medical Sciences, 22 Polna Street, 60-535, Poznan, Poland.
Małgorzata MizgierDepartment of Dietetics, Faculty of Physical Culture in Gorzów Wielkopolski, Poznan University of Physical Education, 13 Estkowskiego Street, 66-400, Gorzów Wielkopolski, Poland.
Poznan University of Medical Sciences · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundResearch studies indicate that polycystic ovary syndrome (PCOS) may increase susceptibility to periodontal disease. The mechanisms that link both conditions are not entirely understood. Thus, the study aimed to investigate the impact of hormonal and metabolic disturbances on the gingival health and salivary levels of tumor necrosis factor (TNF-α), interleukin 1β (IL1-β), and interleukin 6 (IL-6) in adolescent girls with PCOS.

methodsThirty-one patients with PCOS and twenty-eight healthy age-mates (as the control group) were enrolled in the study. Individuals with PCOS underwent blood tests for the determination of hormonal and metabolic parameters. Saliva samples were collected to measure salivary testosterone and proinflammatory cytokines in both studied groups. Calibrated dentist assessed oral hygiene and gingival health of all subjects.

resultsSalivary testosterone was significantly higher in the study group (p = 0.0007). The groups did not differ significantly concerning periodontal parameters. Patients with PCOS revealed higher levels of salivary cytokines (p < 0.0001). Gingival index (GI) and the percentage of sites bleeding upon probing (BOP%) were positively correlated with the plaque index (PI) in both groups (r

conclusionsGingival health of the examined population was associated primarily with oral hygiene and, to a lesser extent, with the hormonal and metabolic profile. Despite similar periodontal parameters in the both studied groups, patients with PCOS revealed significantly higher levels of proinflammatory cytokines in saliva, which might be the manifestation of the systemic low-grade inflammation associated with PCOS.

Indexed as

Insulin ResistancePolycystic Ovary SyndromeAdolescentBody Mass IndexCytokinesFemaleHumansSalivaCytokinesBody Mass IndexGingivitisHyperandrogenismInsulin resistanceLipid profilePolycystic ovary syndromeSalivary cytokinesTestosterone

Identifiers

PMID33849511
PMCPMC8045362
OpenAlexW3152520763

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.