ArticleJournal of psychiatric research2021
Amygdala hyperconnectivity in the paranoid state: A transdiagnostic study.
Article in Journal of psychiatric research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Nonverbal correlates of paranoid ideation - a systematic literature review.Psychological medicine · 2025Pooled it
- Prediction modeling in transdiagnostic risk: results from the PROCAN study.Brain imaging and behavior · 2026Article
- Functional network organization is locally atypical in children, adolescents, and young adults with congenital heart disease.NeuroImage. Clinical · 2026Article
- I fear you're getting too close: neural correlates of personal space violation in paranoia.Schizophrenia (Heidelberg, Germany) · 2025Article
- A counterweight model for understanding and treating persecutory delusions.Psychological medicine · 2025Article
- Distress and Negative Subtypes of Schizophrenia: Identification, Characterization, and Neurostructural Profiles.Schizophrenia bulletin open · 2025Article
- Fear and Anxiety in Schizophrenia: A Focus on Development, Assessment, and Mechanisms.Current topics in behavioral neurosciences · 2025Review
- A transcriptomic atlas of the human brain reveals genetically determined aspects of neuropsychiatric health.American journal of human genetics · 2024Article
- Media Use and Its Associations With Paranoia in Schizophrenia and Bipolar Disorder: Ecological Momentary Assessment.JMIR mental health · 2024Article
- Changes in responses of the amygdala and hippocampus during fear conditioning are associated with persecutory beliefs.Scientific reports · 2024Article
- Fibre density and fibre-bundle cross-section of the corticospinal tract are distinctly linked to psychosis-specific symptoms in antipsychotic-naïve patients with first-episode schizophrenia.European archives of psychiatry and clinical neuroscience · 2023Article
- A preliminary investigation of paranoia variability and its association with social functioning.Schizophrenia research. Cognition · 2022Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundParanoia significantly contributes to social impairments across clinical diagnoses, and amygdala dysfunction has been identified as a neurobiological marker of paranoia among individuals with schizophrenia. Therefore, we aimed to investigate amygdala functional connectivity (FC) in paranoia across diagnoses.
methodsForty-five patients with recent history of clinically significant paranoid ideation and a current DSM-5 diagnosis of any disorder underwent resting-state functional magnetic resonance imaging either in a paranoid (N = 23) or non-paranoid (N = 22) state. Amygdala FC were compared between paranoid and non-paranoid patients. Supplemental correlation analyses between amygdala FC and paranoia score were performed separately in patients and a non-equivalent healthy control (HC; N = 60) group.
resultsIncreased FC was found between right amygdala and the prefrontal cortex (PFC) [bilateral medial superior frontal gyrus, anterior cingulate, medial frontal gyrus, the triangular part and the opercular part of the inferior frontal gyrus (IFG); right orbital part of IFG], the frontal cortex (bilateral median cingulate, left precentral gyrus), and subcortical areas (right insula) in the paranoid group compared with the non-paranoid group. No significant between-group differences were observed in left amygdala FC. FC between right amygdala and PFC and frontal cortex was positively correlated with paranoia in patient and HC groups.
conclusionParanoia is associated with right amygdala hyperconnectivity with PFC, frontal cortex, and insula. This hyperconnectivity was evident regardless of diagnosis and therefore identify a likely transdiagnostic neural mechanism, which may help to identify treatment targets that could potentially improve the social functioning of individuals with clinical diagnoses.
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