Evidence map›Paper›PMID 33848794›Full record

ArticleStem cell research2021

Hypoxia depletes contaminating CD45

Wendi Guo, Kassandra V Spiller, Jackie Tang, Courtney M Karner, Matthew J Hilton, Colleen Wu

Open access · goldAbstract read
In one paragraph

Article in Stem cell research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. [Effects of leptin on proliferation and differentiation of hypoxic rat retinal progenitor cellsNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Wendi GuoDepartment of Orthopaedic Surgery, Duke University School of Medicine, USA; Department of Pharmacology & Cancer Biology, Duke University School of Medicine, USA.
Kassandra V SpillerDepartment of Orthopaedic Surgery, Duke University School of Medicine, USA.
Jackie TangDepartment of Orthopaedic Surgery, Duke University School of Medicine, USA.
Courtney M KarnerDepartment of Orthopaedic Surgery, Duke University School of Medicine, USA; Department of Cell Biology, Duke University School of Medicine, USA.
Matthew J HiltonDepartment of Orthopaedic Surgery, Duke University School of Medicine, USA; Department of Cell Biology, Duke University School of Medicine, USA.
Colleen WuDepartment of Orthopaedic Surgery, Duke University School of Medicine, USA; Department of Cell Biology, Duke University School of Medicine, USA; Department of Pharmacology & Cancer Biology, Duke University School of Medicine, USA. Electronic address: colleen.wu@duke.edu.
Duke University · US

Funding

Role of Glutamine Metabolism During Osteoblast Differentiation and Bone FormationR01AR071967 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI Courtney Michael Karner · 2018 to 2026
$3.5M
Notch Signaling in Endochondral Bone DevelopmentR01AR071722 · NIAMS · DUKE UNIVERSITY · PI HILTON, MATTHEW J. · 2018 to 2022
$1.8M
The Role of Proline Metabolism During Osteoblast Differentiation and Bone FormationR01AR076325 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI KARNER, COURTNEY MICHAEL · 2020 to 2024
$1.6M
NIAMS NIH HHS R01 AR071967NIAMS NIH HHS R01 AR076325
6 · The paper itself

Abstract

Culture expanded bone marrow stromal cells (BMSCs) are easily isolated, can be grown rapidly en masse, and contain both skeletal stem cells (SSCs) and multipotent mesenchymal progenitors (MMPs). Despite this functional heterogeneity, BMSCs continue to be utilized for many applications due to the lack of definitive and universally accepted markers to prospectively identify and purify SSCs. Isolation is widely based on adherence to tissue culture plastic; however, high hematopoietic contamination is a significant impediment in murine models. Remarkably, when cultured at a physiological oxygen tension of 1% O

Indexed as

Hematopoietic Stem Cell TransplantationMesenchymal Stem CellsAnimalsBone Marrow CellsCell DifferentiationCells, CulturedHypoxiaMiceStromal Cells

Identifiers

PMID33848794
PMCPMC9351700
OpenAlexW3147501002

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.