Evidence map›Paper›PMID 33848732›Full record

ArticleCell calcium2021

TRPA1 channel: New kid in the 'neurovascular coupling' town.

Maria Sancho, Mark T Nelson

Open access · greenAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell calcium, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Maria SanchoDepartment of Pharmacology, University of Vermont, Burlington, VT, USA.
Mark T NelsonDepartment of Pharmacology, University of Vermont, Burlington, VT, USA; Division of Cardiovascular Sciences, University of Manchester, Manchester, UK. Electronic address: mark.nelson@uvm.edu.
University of Vermont · US

Funding

Vermont Center for Cardiovascular and Brain HealthP20GM135007 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Kathryn H Morelli · 2020 to 2026
$17.4M
Capillaries as a Sensory Web that Controls Cerebral Blood Flow in Health and DiseaseR35HL140027 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2019 to 2025
$6.3M
Ion Channel Dysfunction in Small Vessel Disease of the BrainR01NS110656 · NINDS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2019 to 2023
$2.6M
NHLBI NIH HHS R35 HL140027NIGMS NIH HHS P20 GM135007NINDS NIH HHS R01 NS110656
6 · The paper itself

Abstract

The just-in time delivery of oxygen and nutrients to active brain regions to support function (functional hyperemia; FH) is mediated by not yet fully understood mechanisms collectively referred to as 'neurovascular coupling' (NVC). In a recent publication (eLife 2021) Thakore et al. provide profound mechanistic insight how the capillary endothelial transient receptor potential ankyrin 1 (TRPA1) channel contribute to blood flow control and functional hyperemia in the brain.

Indexed as

Neurovascular CouplingTransient Receptor Potential ChannelsBrainTRPA1 Cation ChannelTransient Receptor Potential ChannelsTRPA1 Cation ChannelCalcium signalingCapillary endotheliumCerebral blood flowFunctional hyperemiaNeurovascular couplingTRPA1 channels

Identifiers

PMID33848732
PMCPMC8628301
OpenAlexW3145528625

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.