Evidence map›Paper›PMID 33848598›Full record

ArticleBiochimica et biophysica acta. General subjects2021

A property fine-tuned sulfobetaine cholesterol derivative for membrane protein structural biology.

Thi Kim Hoang Trinh, Weihua Qiu, Meg Thornton, Everett E Carpenter, Youzhong Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimica et biophysica acta. General subjects, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Cholesterol-dependent enzyme activity of human TSPO1.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Thi Kim Hoang TrinhDepartment of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA; Institute for Structural Biology, Drug Discovery and Development, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23219, USA.
Weihua QiuDepartment of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA; Institute for Structural Biology, Drug Discovery and Development, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23219, USA.
Meg ThorntonDepartment of Chemistry, College of Humanities and Sciences, Virginia Commonwealth University, Richmond, VA 23284, USA.
Everett E CarpenterDepartment of Chemistry, College of Humanities and Sciences, Virginia Commonwealth University, Richmond, VA 23284, USA.
Youzhong GuoDepartment of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA; Institute for Structural Biology, Drug Discovery and Development, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23219, USA. Electronic address: yguo4@vcu.edu.

Funding

Proposal for an Administrative Supplement for Equipment Purchases for NIGMS Awardees NOT-GM-22-017R01GM132329 · NIGMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI GUO, YOUZHONG · 2019 to 2022
$1.9M
NIGMS NIH HHS R01 GM132329
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

BetaineCholesterolHumansReceptors, GABASolubilityBetaineCholesterolReceptors, GABAsulfobetaineTSPO protein, humanCHEAPSCholesterolMembrane proteinTSPO

Identifiers

PMID33848598
PMCPMC8165746

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.