Evidence map›Paper›PMID 33848513›Full record

ArticleExperimental neurology2021

FDA-approved 5-HT

Epiphani C Simmons, Natalie E Scholpa, Rick G Schnellmann

Open access · greenAbstract read
In one paragraph

Article in Experimental neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 30 citations in OpenAlex.

  1. Circuit Reconstruction after Traumatic Spinal Cord Injury by Cellular and Pharmacological Approaches.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. 5-HTFrontiers in cellular neuroscience · 2024
    Article
  10. Article
  11. The 5-HTNature reviews. Neurology · 2023
    Review
  12. Article
  13. [Advances of the role of mitochondrial dysfunction in the spinal cord injury and its relevant treatments].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2022
    Review
  14. Mitochondrial function in spinal cord injury and regeneration.Cellular and molecular life sciences : CMLS · 2022
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Epiphani C SimmonsDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, United States of America; Department of Neurosciences, College of Medicine, University of Arizona, Tucson, AZ, United States of America. Electronic address: esimmons@pharmacy.arizona.edu.
Natalie E ScholpaDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, United States of America; Southern Arizona VA Health Care System, Tucson, AZ, United States of America. Electronic address: scholpa@pharmacy.arizona.edu.
Rick G SchnellmannDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, United States of America; Department of Neurosciences, College of Medicine, University of Arizona, Tucson, AZ, United States of America; College of Pharmacy, University of Arizona, Tucson, AZ, United States of America; Southern Arizona VA Health Care System, Tucson, AZ, United States of America; Southwest Environmental Health Science Center, University of Arizona, Tucson, AZ, United States of America; Center for Innovation in Brain Science, University of Arizona, Tucson, AZ, United States of America. Electronic address: schnell@pharmacy.arizona.edu.
University of Arizona · USCenter for Innovation · US

Funding

Translational research in Alzheimer’s Disease and Related Dementias (TRADD)T32AG061897 · NIA · UNIVERSITY OF ARIZONA · PI BRINTON, ROBERTA EILEEN · 2018 to 2022
$1.3M
5-HT1F receptor mediated mitochondrial biogenesis for the treatment of spinal cord injuryF31NS115413 · NINDS · UNIVERSITY OF ARIZONA · PI SIMMONS, EPIPHANI · 2020 to 2020
$37k
BLRD VA I01 BX004868BLRD VA IK2 BX005218NIA NIH HHS T32 AG061897NINDS NIH HHS F31 NS115413
6 · The paper itself

Abstract

Vascular and mitochondrial dysfunction are well-established consequences of spinal cord injury (SCI). Evidence suggests mitigating these dysfunctions may be an effective approach in treating SCI. The goal of this study was to elucidate if mitochondrial biogenesis (MB) induction with a new, selective and FDA-approved 5-hydroxytryptamine receptor 1F (5-HT

Indexed as

Organelle BiogenesisAnimalsBenzamidesBlood-Brain BarrierFemaleLocomotionMiceMice, Inbred C57BLMitochondriaPiperidinesPyridinesRecovery of FunctionSerotonin Receptor AgonistsSpinal CordSpinal Cord InjuriesBenzamideslasmiditanPiperidinesPyridinesSerotonin Receptor Agonists5-HT(1F) receptorBlood-spinal cord barrierLasmiditanLocomotor recoveryMitochondrial biogenesisMitochondrial respirationSpinal cord injury

Identifiers

PMID33848513
PMCPMC9013231
OpenAlexW3155830374

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.