Evidence map›Paper›PMID 33848487›Full record

ArticleCurrent biology : CB2021

Cancer biology: Messages in extracellular vesicles depend on centrosome number.

Cayla E Jewett, Chad G Pearson

Abstract readComment
PubMed Publisher
In one paragraph

Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Cayla E JewettDepartment of Cell and Developmental Biology, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address: Cayla.Jewett@cuanschutz.edu.
Chad G PearsonDepartment of Cell and Developmental Biology, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address: Chad.Pearson@cuanschutz.edu.

Funding

Centriole assembly and function for centrosome and cilia biologyR35GM140813 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI CHAD G PEARSON · 2021 to 2026
$3.5M
Mechanisms of centriole assembly and stabilityR01GM099820 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI PEARSON, CHAD G · 2012 to 2020
$2.9M
Centrosome regulation of trafficking, ciliogenesis and cilia-dependent signalingR01GM138415 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI PEARSON, CHAD G · 2020 to 2020
$306k
Medical Research Council MR/P009417/1NIGMS NIH HHS R01 GM099820NIGMS NIH HHS R01 GM138415NIGMS NIH HHS R35 GM140813
6 · The paper itself

Abstract

Extra centrosomes are linked to cancer-associated errors in cell division, metastasis and signaling. A new study reveals that centrosome amplification disrupts lysosome function, leading to the release of small extracellular vesicles and to invasive activity in pancreatic cells.

Indexed as

Extracellular VesiclesNeoplasmsBiologyCell DivisionCentrosomeHumans

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.