ArticleNeuron2021
Multidimensional population activity in an electrically coupled inhibitory circuit in the cerebellar cortex.
Article in Neuron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 30 citations in OpenAlex.
- Low-dimensional population dynamics in the brainstem gate REM sleep.Nature neuroscience · 2026Article
- Cerebellar tonic inhibition orchestrates the maturation of information processing and motor coordination.Experimental & molecular medicine · 2026Article
- A computational model of the cerebellar granular layer calibrated to experimental data for studying inhibition and sensory encoding.Scientific reports · 2025Article
- Coincidence detection between apical and basal dendrites drives STDP in cerebellar Golgi cells.Communications biology · 2025Article
- Article
- GlyT2-Positive Interneurons Regulate Timing and Variability of Information Transfer in a Cerebellar-Behavioral Loop.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- A deep-learning strategy to identify cell types across species from high-density extracellular recordings.bioRxiv : the preprint server for biology · 2024Article
- Local synaptic inhibition mediates cerebellar granule cell pattern separation and enables learned sensorimotor associations.Nature neuroscience · 2024Article
- Increased understanding of complex neuronal circuits in the cerebellar cortex.Frontiers in cellular neuroscience · 2024Review
- Early molecular layer interneuron hyperactivity triggers Purkinje neuron degeneration in SCA1.Neuron · 2023Article
- An emergent temporal basis set robustly supports cerebellar time-series learning.Journal of neurophysiology · 2023Article
- Synaptic basis of a sub-second representation of time in a neural circuit model.Nature communications · 2022Article
- The Cerebellar Cortex.Annual review of neuroscience · 2022Review
- Neurophotonic tools for microscopic measurements and manipulation: status report.Neurophotonics · 2022Article
- Cerebellum as a kernel machine: A novel perspective on expansion recoding in granule cell layer.Frontiers in computational neuroscience · 2022Article
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2 authors at 1 institution in 1 country.
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Abstract
Inhibitory neurons orchestrate the activity of excitatory neurons and play key roles in circuit function. Although individual interneurons have been studied extensively, little is known about their properties at the population level. Using random-access 3D two-photon microscopy, we imaged local populations of cerebellar Golgi cells (GoCs), which deliver inhibition to granule cells. We show that population activity is organized into multiple modes during spontaneous behaviors. A slow, network-wide common modulation of GoC activity correlates with the level of whisking and locomotion, while faster (<1 s) differential population activity, arising from spatially mixed heterogeneous GoC responses, encodes more precise information. A biologically detailed GoC circuit model reproduced the common population mode and the dimensionality observed experimentally, but these properties disappeared when electrical coupling was removed. Our results establish that local GoC circuits exhibit multidimensional activity patterns that could be used for inhibition-mediated adaptive gain control and spatiotemporal patterning of downstream granule cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.