Evidence map›Paper›PMID 33848469›Full record

ArticleCell stem cell2021

Early stem cell aging in the mature brain.

Albina Ibrayeva, Maxwell Bay, Elbert Pu, David J Jörg, Lei Peng, Heechul Jun, Naibo Zhang, Daniel Aaron, Congrui Lin, Galen Resler and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell stem cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 137 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Dynamic expression of lamin B1 during adult neurogenesis in the vertebrate brain.Developmental dynamics : an official publication of the American Association of Anatomists · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Hallmarks of stem cell aging.Cell stem cell · 2025
    Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Albina IbrayevaEli and Edythe Broad Center for Regenerative Medicine & Stem Cell Research at USC, University of Southern California, Los Angeles, CA 90033, USA; Department of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, CA 90033, USA; USC Davis School - Buck Institute Graduate Program in the Biology of Aging, University of Southern California, Los Angeles, CA 90033, USA.
Maxwell BayEli and Edythe Broad Center for Regenerative Medicine & Stem Cell Research at USC, University of Southern California, Los Angeles, CA 90033, USA; Department of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, CA 90033, USA; Neuroscience Graduate Program, W. M. Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Elbert PuEli and Edythe Broad Center for Regenerative Medicine & Stem Cell Research at USC, University of Southern California, Los Angeles, CA 90033, USA; Department of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, CA 90033, USA.
David J JörgCavendish Laboratory, Department of Physics, University of Cambridge, Cambridge CB3 0HE, UK; Gurdon Institute, University of Cambridge, Cambridge CB3 0HE, UK.
Lei PengEli and Edythe Broad Center for Regenerative Medicine & Stem Cell Research at USC, University of Southern California, Los Angeles, CA 90033, USA; Department of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, CA 90033, USA; Neuroscience Graduate Program, W. M. Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Heechul JunDepartment of Neurological Surgery, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
Naibo ZhangEli and Edythe Broad Center for Regenerative Medicine & Stem Cell Research at USC, University of Southern California, Los Angeles, CA 90033, USA; Department of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Daniel AaronEli and Edythe Broad Center for Regenerative Medicine & Stem Cell Research at USC, University of Southern California, Los Angeles, CA 90033, USA; Department of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Congrui LinEli and Edythe Broad Center for Regenerative Medicine & Stem Cell Research at USC, University of Southern California, Los Angeles, CA 90033, USA; Department of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Galen ReslerEli and Edythe Broad Center for Regenerative Medicine & Stem Cell Research at USC, University of Southern California, Los Angeles, CA 90033, USA; Department of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Axel HidalgoEli and Edythe Broad Center for Regenerative Medicine & Stem Cell Research at USC, University of Southern California, Los Angeles, CA 90033, USA; Department of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Mi-Hyeon JangDepartment of Neurological Surgery, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
Benjamin D SimonsCavendish Laboratory, Department of Physics, University of Cambridge, Cambridge CB3 0HE, UK; Gurdon Institute, University of Cambridge, Cambridge CB3 0HE, UK.
Michael A BonaguidiEli and Edythe Broad Center for Regenerative Medicine & Stem Cell Research at USC, University of Southern California, Los Angeles, CA 90033, USA; Department of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, CA 90033, USA; USC Davis School - Buck Institute Graduate Program in the Biology of Aging, University of Southern California, Los Angeles, CA 90033, USA; Neuroscience Graduate Program, W. M. Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA 90033, USA; Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90033, USA; Davis School of Gerontology, University of Southern California, Los Angeles, CA 90033, USA. Electronic address: mbonagui@usc.edu.
Broad Center · USUniversity of Southern California · USNeurological Surgery · USUniversity of Cambridge · GB

Funding

PQ#12; Targeting Nampt-mediated NAD+ metabolism in chemobrainR01CA242158 · NCI · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI JANG, MI-HYEON · 2019 to 2023
$2.8M
Training in Developmental Biology, Stem Cells and RegenerationT32HD060549 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Gage D Crump · 2011 to 2026
$2.5M
Role of BubR1 as a juvenile protective factor in hippocampal agingR01AG058560 · NIA · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI JANG, MI-HYEON · 2018 to 2022
$2.3M
Mechanisms Underlying Neural Stem Cell Heterogeneity in the Adult HippocampusR00NS080913 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BONAGUIDI, MICHAEL · 2015 to 2017
$747k
Mechanisms Underlying Adult Neural Stem Cell HomeostasisR56AG064077 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BONAGUIDI, MICHAEL · 2019 to 2019
$611k
NCI NIH HHS R01 CA242158NIA NIH HHS R01 AG058560NIA NIH HHS R56 AG064077NICHD NIH HHS T32 HD060549NINDS NIH HHS R00 NS080913Wellcome TrustWellcome Trust 098357/Z/12/Z
6 · The paper itself

Abstract

Stem cell dysfunction drives many age-related disorders. Identifying mechanisms that initially compromise stem cell behavior represent early targets to promote tissue function later in life. Here, we pinpoint multiple factors that disrupt neural stem cell (NSC) behavior in the adult hippocampus. Clonal tracing showed that NSCs exhibit asynchronous depletion by identifying short-term NSCs (ST-NSCs) and long-term NSCs (LT-NSCs). ST-NSCs divide rapidly to generate neurons and deplete in the young brain. Meanwhile, multipotent LT-NSCs are maintained for months but are pushed out of homeostasis by lengthening quiescence. Single-cell transcriptome analysis of deep NSC quiescence revealed several hallmarks of molecular aging in the mature brain and identified tyrosine-protein kinase Abl1 as an NSC aging factor. Treatment with the Abl inhibitor imatinib increased NSC activation without impairing NSC maintenance in the middle-aged brain. Our study indicates that hippocampal NSCs are particularly vulnerable and adaptable to cellular aging.

Indexed as

Neural Stem CellsNeurogenesisBrainCellular SenescenceHippocampusAbladult neurogenesisagingbioinformaticscell fateclonal analysishippocampusImatinibinterventionproliferationquiescencesingle cell RNA-seqstem cell

Identifiers

PMID33848469
PMCPMC10069280
OpenAlexW3153549711

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.