Evidence map›Paper›PMID 33848447›Full record

ArticleAmerican journal of respiratory and critical care medicine2021

Secreted Extracellular Cyclophilin A Is a Novel Mediator of Ventilator-induced Lung Injury.

Marissa W Koh, Rhianna F Baldi, Sanooj Soni, Rhodri Handslip, Ying Ying Tan, Kieran P O'Dea, Miroslav Malesevic, Daniel F McAuley, Cecilia M O'Kane, Brijesh V Patel and 2 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Ventilator-induced Lung Injury Promotes Inflammation within the Pleural Cavity.American journal of respiratory cell and molecular biology · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. The Lung-Brain Axis in Ventilator-induced Brain Injury: Enter IL-6.American journal of respiratory cell and molecular biology · 2021
    Article
  12. The CypA-netics of Ventilator-induced Lung Injury.American journal of respiratory and critical care medicine · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Marissa W KohDivision of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, London, United Kingdom.
Rhianna F BaldiDivision of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, London, United Kingdom.
Sanooj SoniDivision of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, London, United Kingdom.
Rhodri HandslipDivision of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, London, United Kingdom.
Ying Ying TanDivision of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, London, United Kingdom.
Kieran P O'DeaDivision of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, London, United Kingdom.
Miroslav MalesevicInstitute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, Halle, Germany; and.
Daniel F McAuleyWellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom.
Cecilia M O'KaneWellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom.
Brijesh V PatelDivision of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, London, United Kingdom.
Masao TakataDivision of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, London, United Kingdom.
Michael R WilsonDivision of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, London, United Kingdom.ORCID 0000-0002-9747-8910
Imperial College London · GBQueen's University Belfast · GBMartin Luther University Halle-Wittenberg · DE

Funding

Medical Research Council MR/M018164/1
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAnti-Inflammatory AgentsCells, CulturedCOVID-19Cyclophilin AHumansInflammationMaleMiceModels, AnimalRespiration, ArtificialRespiratory Distress SyndromeRespiratory MucosaSARS-CoV-2Ventilator-Induced Lung InjuryAnti-Inflammatory AgentsCyclophilin Aacute respiratory distress syndromeanimal modelcyclosporinmatrix metalloproteinasemechanical ventilation

Identifiers

PMID33848447
PMCPMC8480235
OpenAlexW3153201529

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.