ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2021
Temporal trends in the quality of deceased donor kidneys and kidney transplant outcomes in Europe: an analysis by the ERA-EDTA Registry.
Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 23 citations in OpenAlex.
- Predicting long-term allograft outcomes in kidney transplant recipients using a machine learning approach: a 5-year retrospective cohort study.Renal failure · 2026Article
- Xenotransplantation and the organ shortage: evaluating policy priorities.Current opinion in organ transplantation · 2026Review
- Trends in the epidemiology of paediatric kidney transplantation in Europe between 2010 and 2021: an ESPN/ERA Registry study.Clinical kidney journal · 2026Article
- Kidney Donor Risk Index and Cardiovascular Complications in a Long-Term Follow-Up Observation.Journal of clinical medicine · 2025Article
- International comparison and time trends of first kidney transplant recipient characteristics across Europe: an ERA Registry study.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024Article
- Trends in Survival for Adult Organ Transplantation.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2024Article
- Increasing numbers and improved overall survival of patients on kidney replacement therapy over the last decade in Europe: an ERA Registry study.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023Article
- Evaluation of Kidney Donor Risk Index/Kidney Donor Profile Index as Predictor Tools of Deceased-Donor Kidney Transplant Outcomes in a Greek Cohort.Journal of clinical medicine · 2023Article
- Population Characteristics and Clinical Outcomes from the Renal Transplant Outcome Prediction Validation Study (TOPVAS).Journal of clinical medicine · 2022Article
- Beyond Graft Survivl: A National Cohort Study Quantifying the Impact of Increasing Kidney Donor Profile Index on Recipient Outcomes 1 Year Post-transplantation.Transplantation direct · 2022Article
- Systematic review of intra-operative duplex scanning during renal transplantation.Australasian journal of ultrasound in medicine · 2022Review
- Deceased Donor Characteristics and Kidney Transplant Outcomes.Transplant international : official journal of the European Society for Organ Transplantation · 2022Review
- Editorial: Advances in the diagnosis and treatment in kidney transplantation.Frontiers in medicine · 2022Article
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Authors and funding
14 authors at 11 institutions in 9 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe investigated 10-year trends in deceased donor kidney quality expressed as the kidney donor risk index (KDRI) and subsequent effects on survival outcomes in a European transplant population.
methodsTime trends in the crude and standardized KDRI between 2005 and 2015 by recipient age, sex, diabetic status and country were examined in 24 177 adult kidney transplant recipients in seven European countries. We determined 5-year patient and graft survival probabilities and the risk of death and graft loss by transplant cohort (Cohort 1: 2005-06, Cohort 2: 2007-08, Cohort 3: 2009-10) and KDRI quintile.
resultsThe median crude KDRI increased by 1.3% annually, from 1.31 [interquartile range (IQR) 1.08-1.63] in 2005 to 1.47 (IQR 1.16-1.90) in 2015. This increase, i.e. lower kidney quality, was driven predominantly by increases in donor age, hypertension and donation after circulatory death. With time, the gap between the median standardized KDRI in the youngest (18-44 years) and oldest (>65 years) recipients widened. There was no difference in the median standardized KDRI by recipient sex. The median standardized KDRI was highest in Austria, the Netherlands and the Basque Country (Spain). Within each transplant cohort, the 5-year patient and graft survival probability were higher for the lowest KDRIs. There was no difference in the patient and graft survival outcomes across transplant cohorts, however, over time the survival probabilities for the highest KDRIs improved.
conclusionsThe overall quality of deceased donor kidneys transplanted between 2005 and 2015 has decreased and varies between age groups and countries. Overall patient and graft outcomes remain unchanged.
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