ArticleEnvironmental health perspectives2021
Potential for Manganese-Induced Neurologic Harm to Formula-Fed Infants: A Risk Assessment of Total Oral Exposure.
Article in Environmental health perspectives, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Essential and Potentially Toxic Elements in Commercial Milk Formulas: Health Risk Assessment Through a Systematic Review and Meta-analysis.Biological trace element research · 2026Review
- Analysis of the Elemental Composition of Milk Formulae: Impact on the Nutritional Status of Infants From Birth to 1 Year of Age.Biological trace element research · 2026Article
- Deciphering the Structure and Genetic Basis of Adaptive Mechanism of Soil Microbial Communities in a Manganese Electrolysis Plant.Microorganisms · 2025Article
- Manganese exposure assessment in formula-fed infants in Israel.Israel journal of health policy research · 2025Article
- A Mixed Methods Approach to Understanding the Public Health Impact of a School-Based Citizen Science Program to Reduce Arsenic in Private Well Water.Environmental health perspectives · 2024Article
- Urinary biomarkers of exposure to toxic and essential elements: A comparison of infants fed with human milk or formula.Environmental epidemiology (Philadelphia, Pa.) · 2024Article
- Manganese in residential drinking water from a community-initiated case study in Massachusetts.Journal of exposure science & environmental epidemiology · 2024Article
- Article
- Exposures and potential health implications of contaminant mixtures in linked source water, finished drinking water, and tapwater from public-supply drinking water systems in Minneapolis/St. Paul area, USA.Environmental science : water research & technology · 2023Article
- Comparative susceptibility of children and adults to neurological effects of inhaled manganese: A review of the published literature.Environmental research · 2023Review
- Article
- Animal Models of Childhood Exposure to Lead or Manganese: Evidence for Impaired Attention, Impulse Control, and Affect Regulation and Assessment of Potential Therapies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Review
- Article
- Manganese-Induced Toxicity inInternational journal of molecular sciences · 2022Article
- Exposing the role of metals in neurological disorders: a focus on manganese.Trends in molecular medicine · 2022Review
- Drinking Water Quality and Public Health in the Kathmandu Valley, Nepal: Coliform Bacteria, Chemical Contaminants, and Health Status of Consumers.Journal of environmental and public health · 2022Article
- Effects of Manganese on Genomic Integrity in the Multicellular Model OrganismInternational journal of molecular sciences · 2021Article
- Manganese Intake in Babies: Drinking Water plus Formula Can Cause High Exposures.Environmental health perspectives · 2021Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHigh oral exposure and biological vulnerabilities may put formula-fed infants at risk for manganese-induced neurotoxicity.
objectivesWe sought to characterize manganese concentrations in public drinking water and prepared infant formulas commonly purchased in the United States, integrate information from these sources into a health risk assessment specific to formula-fed infants, and examine whether households that receive water with elevated manganese concentrations avoid or treat the water, which has implications for formula preparation.
methodsManganese was measured in 27 infant formulas and nearly all Minnesota community public water systems (CPWS). The risk assessment produced central tendency and upper-end exposure estimates that were compared to a neonatal animal-based health reference dose (RfD) and considered possible differences in bioavailability. A survey study assessed esthetic concerns, treatment, and use of water in a Twin Cities community with various levels of manganese in drinking water.
resultsTen percent of CPWSs were estimated to exceed the EPA health advisory level of DISCUSSION: Excessive exposure to manganese early in life can have long-lasting neurological impacts. This assessment underscores the potential for manganese overexposure in formula-fed infants. U.S. agencies that regulate formula and drinking water must work collaboratively to assess and mitigate potential risks. https://doi.org/10.1289/EHP7901.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.