ArticleDrugs & aging2021
International Validation of the Turkish Inappropriate Medication Use in the Elderly (TIME) Criteria Set: A Delphi Panel Study.
Article in Drugs & aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Relationship between polypharmacy, sarcopenia and drug classes in hospitalized older patients.Aging clinical and experimental research · 2026Article
- Potentially Inappropriate Prescription and Its Association with Index Hospitalization: A Multicenter, Cross-Sectional Study Using TIME Criteria.Drugs & aging · 2026Observational
- Medication Therapy Management Guided by TIME Criteria in Nursing Home Residents: A Before-After Observational Study.Journal of clinical medicine · 2026Article
- Potentially inappropriate prescriptions in acutely admitted older patients: a development study to create a clinical decision support tool using a Delphi process.European geriatric medicine · 2026Article
- Investigating Potential Prescribing Cascades Resulting in Prochlorperazine Prescription: An Exploratory Analysis of Antihypertensives and NSAIDs.Drugs & aging · 2026Article
- Managing Bone Fragility in Older Adults with Diabetes: Pathophysiology, Assessment, and Therapeutic Considerations.Drugs & aging · 2026Review
- Potentially inappropriate medication use by TIME criteria in nursing home residents and its relationship with common geriatric syndromes.European geriatric medicine · 2025Observational
- Deprescribing Antipsychotics and Proton Pump Inhibitors in Long-Term Care: A Prescribing Portraits Approach.Drugs & aging · 2025Article
- Article
- Management of Type 2 Diabetes in Frail Older Adults.Drugs & aging · 2023Article
- European position paper on polypharmacy and fall-risk-increasing drugs recommendations in the World Guidelines for Falls Prevention and Management: implications and implementation.European geriatric medicine · 2023Article
- Management of use of urinary antimuscarinics and alpha blockers for benign prostatic hyperplasia in older adults at risk of falls: a clinical review.European geriatric medicine · 2023Review
- Optimal use of oral nutritional supplements (ONS) in medical nutrition therapy: ONS consensus report from KEPAN.European journal of clinical nutrition · 2023Review
- Polypharmacy, potentially inappropriate medications and associated factors among older adults with hypertension in primary care.Revista brasileira de enfermagem · 2023Article
- Potentially inappropriate medications based on TIME criteria and risk of in-hospital mortality in COVID-19 patients.Revista da Associacao Medica Brasileira (1992) · 2022Article
Corrections and comments
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Authors and funding
16 authors at 10 institutions in 8 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveExplicit screening tools and implicit evaluation methods have been developed to assist healthcare professionals in the management of pharmacotherapy in older adults. As prescribing habits and locally available medications vary considerably between countries, guides tailored to the needs of specific regions may be required. We aimed to report the results of the international Delphi validation study for the Turkish Inappropriate Medication use in the Elderly (TIME) criteria set, which aims to detect inappropriate prescribing in older adults in Eastern Europe.
methodsThe study was conducted between June 2019 and March 2020. Delphi rounds were conducted by the TIME international working group, which included 11 internationally recognized experts in geriatric pharmacotherapy as Delphi panelists. They were asked to indicate to what extent they agreed or disagreed with each TIME criterion, taking into account both the available evidence and their own experience. We used a five-point Likert scale from 1 (strongly agree) to 5 (strongly disagree) and an online software program (SurveyMonkey
resultsAfter three Delphi rounds, 134 criteria were accepted and seven criteria were rejected, while 12 criteria did not achieve consensus, and so were not included in the final validated set of TIME criteria.
conclusionWe developed the internationally validated TIME criteria set based on a Delphi process involving international experts. The validation study suggests that the TIME criteria set can be applied in both central and Eastern European settings. Further studies are needed to assess the utility and benefit of the TIME criteria in reducing inappropriate drug use and improving clinical outcomes.
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