ArticleNeuroscience bulletin2021
Lateral Hypothalamic Area Glutamatergic Neurons and Their Projections to the Lateral Habenula Modulate the Anesthetic Potency of Isoflurane in Mice.
Article in Neuroscience bulletin, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- State-dependent neuronal and network dynamics in the lateral hypothalamus across sevoflurane anesthesia-emergence revealed by microelectrode arrays.Microsystems & nanoengineering · 2026Article
- Anesthetic State-Dependent Bidirectional Control of States of Consciousness via Heterogeneous Medial Septum to Ventral Tegmental Area Circuits under Sevoflurane in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Edinger-Westphal Neurons Contribute to Emergence from Desflurane and Sevoflurane Anesthesia in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Wakefulness regulation of memory encoding and retrieval: structure and activity.National science review · 2026Review
- Current and Developing Approaches for Facilitating Emergence from General Anesthesia.Anesthesiology · 2025Review
- The Somatostatin Pathway Projected from the Basal Forebrain to the Lateral Habenula Promotes Isoflurane Anesthesia Recovery.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Basal Forebrain to Ventral Tegmental Area Glutamatergic Pathway Promotes Emergence from Isoflurane Anesthesia in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neural Network Mechanisms Underlying General Anesthesia: Cortical and Subcortical Nuclei.Neuroscience bulletin · 2024Review
- GABAergic neurons of anterior thalamic reticular nucleus regulate states of consciousness in propofol- and isoflurane-mediated general anesthesia.CNS neuroscience & therapeutics · 2024Article
- Recent advances in neural mechanism of general anesthesia induced unconsciousness: insights from optogenetics and chemogenetics.Frontiers in pharmacology · 2024Review
- Article
- Selective optogenetic modulation of the PBN terminals in the lateral hypothalamic area and basal forebrain regulates emergence from isoflurane anesthesia in mice.BMC anesthesiology · 2023Article
- Activation of astrocytes in the basal forebrain in mice facilitates isoflurane-induced loss of consciousness and prolongs recovery.BMC anesthesiology · 2023Article
- [Activation of GABAergic neurons in the zona incerta accelerates anesthesia induction with sevoflurane and propofol without affecting anesthesia maintenance or awakening in mice].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Article
- GABAergic neurons in the dorsomedial hypothalamus regulate states of consciousness in sevoflurane anesthesia.iScience · 2023Article
- Nucleus accumbens circuit disinhibits lateral hypothalamus glutamatergic neurons contributing to morphine withdrawal memory in male mice.Nature communications · 2023Article
- Medial septum glutamatergic neurons modulate nociception in chronic neuropathic pain via projections to lateral hypothalamus.Frontiers in pharmacology · 2023Article
- Sexual Dimorphism of Inputs to the Lateral Habenula in Mice.Neuroscience bulletin · 2022Article
- Regulation of Neural Circuitry under General Anesthesia: New Methods and Findings.Biomolecules · 2022Review
- Dopaminergic Neurons in the Ventral Tegmental-Prelimbic Pathway Promote the Emergence of Rats from Sevoflurane Anesthesia.Neuroscience bulletin · 2022Article
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The lateral hypothalamic area (LHA) plays a pivotal role in regulating consciousness transition, in which orexinergic neurons, GABAergic neurons, and melanin-concentrating hormone neurons are involved. Glutamatergic neurons have a large population in the LHA, but their anesthesia-related effect has not been explored. Here, we found that genetic ablation of LHA glutamatergic neurons shortened the induction time and prolonged the recovery time of isoflurane anesthesia in mice. In contrast, chemogenetic activation of LHA glutamatergic neurons increased the time to anesthesia and decreased the time to recovery. Optogenetic activation of LHA glutamatergic neurons during the maintenance of anesthesia reduced the burst suppression pattern of the electroencephalogram (EEG) and shifted EEG features to an arousal pattern. Photostimulation of LHA glutamatergic projections to the lateral habenula (LHb) also facilitated the emergence from anesthesia and the transition of anesthesia depth to a lighter level. Collectively, LHA glutamatergic neurons and their projections to the LHb regulate anesthetic potency and EEG features.
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