Evidence map›Paper›PMID 33847910›Full record

ReviewScience China. Life sciences2021

The role and potential application of extracellular vesicles in liver cancer.

Xuewei Qi, Shuzhen Chen, Huisi He, Wen Wen, Hongyang Wang

Open access · hybridAbstract readReview
PubMed Publisher
In one paragraph

Review in Science China. Life sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Review
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  4. Review
  5. Review
  6. Harmonising cellular conversations: decoding the vital roles of extracellular vesicles in respiratory system intercellular communications.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. A hidden translatome in tumors-the coding lncRNAs.Science China. Life sciences · 2023
    Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Emerging Biomimetic Drug Delivery Nanoparticles Inspired by Extracellular Vesicles.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Xuewei Qi *Cancer Research Center, The First Affiliated Hospital, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China.
Shuzhen Chen *National Center for Liver Cancer, Second Military Medical University, Shanghai, 200438, China.
Huisi He *National Center for Liver Cancer, Second Military Medical University, Shanghai, 200438, China.
Wen WenNational Center for Liver Cancer, Second Military Medical University, Shanghai, 200438, China. wenwen_smmu@163.com.
Hongyang WangCancer Research Center, The First Affiliated Hospital, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China. hywangk@vip.sina.com.
Second Military Medical University · CNEastern Hepatobiliary Surgery Hospital · CNUniversity of Science and Technology of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver cancer is one of the most common causes of cancer-related death worldwide and mainly includes hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA). Extracellular vesicles (EVs) are membrane-derived nanometer-sized vesicles that can be released by different cell types under normal and pathological conditions and thus play important roles in the transmission of biological information between cells. Increasing evidence suggests that liver cancer cell-derived EVs may help establish a favorable microenvironment to support the proliferation, invasion and metastasis of cancer cells. In this review, we summarized the role of EVs in the tumor microenvironment (TME) during the development and progression of liver cancer. As messenger carriers, EVs are loaded by various biomolecules, such as proteins, RNA, DNA, lipids and metabolites, making them potential liquid biopsy biomarkers for the diagnosis and prognosis of liver cancer. We also highlighted the progress of EVs as antigen carriers and EV-based therapeutics in preclinical studies of liver cancer.

Indexed as

Cell CommunicationTumor MicroenvironmentBiomarkers, TumorExtracellular VesiclesHumansLiver NeoplasmsBiomarkers, TumorEV-based therapyexosomesextracellular vesiclesliver cancermicrovesiclesnoninvasive biomarkertumor microenvironment

Identifiers

PMID33847910
OpenAlexW3154876883

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.