ReviewScience China. Life sciences2021
Dual recombinases-based genetic lineage tracing for stem cell research with enhanced precision.
Review in Science China. Life sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Lineage tracing from cellular heritage to disease destiny.Nature genetics · 2026Review
- Cardiomyocyte proliferation: Advances and insights in macrophage-targeted therapy for myocardial injury.Genes & diseases · 2025Review
- Smooth muscle cell-specific genetic targeting by Myh11-driven Cre(ER) knockin mice.Science China. Life sciences · 2024Article
- Application of Lineage Tracing in Central Nervous System Development and Regeneration.Molecular biotechnology · 2024Review
- Differentiation potential of periodontal Col1Mechanobiology in medicine · 2024Article
- Discovery and characterization of novel Cre-type tyrosine site-specific recombinases for advanced genome engineering.Nucleic acids research · 2023Article
- Perfect duet: Dual recombinases improve genetic resolution.Cell proliferation · 2023Review
- Visualization of in vivo cell-cell contact in the present and in the past.Science China. Life sciences · 2023Article
- Cre-loxP-mediated genetic lineage tracing: Unraveling cell fate and origin in the developing heart.Frontiers in cardiovascular medicine · 2023Review
- Construction and application of a multifunctional CHO cell platform utilizing Cre/Frontiers in bioengineering and biotechnology · 2023Article
- A novel lineage of osteoprogenitor cells with dual epithelial and mesenchymal properties govern maxillofacial bone homeostasis and regeneration after MSFL.Cell research · 2022Article
- Dual Cre and Dre recombinases mediate synchronized lineage tracing and cell subset ablation in vivo.The Journal of biological chemistry · 2022Article
- A New Generation of Lineage Tracing Dynamically Records Cell Fate Choices.International journal of molecular sciences · 2022Review
- Emerging strategies for the genetic dissection of gene functions, cell types, and neural circuits in the mammalian brain.Molecular psychiatry · 2022Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stem cell research has become a hot topic in biology, as the understanding of stem cell biology can provide new insights for both regenerative medicine and clinical treatment of diseases. Accurately deciphering the fate of stem cells is the basis for understanding the mechanism and function of stem cells during tissue repair and regeneration. Cre-loxP-mediated recombination has been widely applied in fate mapping of stem cells for many years. However, nonspecific labeling by conventional cell lineage tracing strategies has led to discrepancies or even controversies in multiple fields. Recently, dual recombinase-mediated lineage tracing strategies have been developed to improve both the resolution and precision of stem cell fate mapping. These new genetic strategies also expand the application of lineage tracing in studying cell origin and fate. Here, we review cell lineage tracing methods, especially dual genetic approaches, and then provide examples to describe how they are used to study stem cell fate plasticity and function in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.