Evidence map›Paper›PMID 33847875›Full record

ArticleForensic science, medicine, and pathology2021

Undiagnosed acromegaly as an underlying cause of sudden death.

Anna Elisabet Borgen, Anne Birgitte Dyhre Bugge, Eva Løbner Lund, Jytte Banner

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Forensic science, medicine, and pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Anna Elisabet BorgenDepartment of Forensic Medicine, Section of Forensic Pathology, University of Copenhagen, Copenhagen, Denmark. annalandmark@gmail.com.ORCID http://orcid.org/0000-0003-2932-1548
Anne Birgitte Dyhre BuggeDepartment of Forensic Medicine, Section of Forensic Pathology, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-7172-4186
Eva Løbner LundRigshospitalet, Department of Pathology, Copenhagen University Hospital, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-6291-5893
Jytte BannerDepartment of Forensic Medicine, Section of Forensic Pathology, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-7559-1285
University of Copenhagen · DKCopenhagen University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a case of sudden death in a 31-year-old male diagnosed at autopsy with clinical undiagnosed acromegaly. The purpose of this report is to underline the importance of health professionals reacting to phenotypic acromegaly, such as acral enlargement and/or unexplained hypertension, including a range of severe comorbidities, to avoid a fatal outcome. Recent studies have shown that the increased mortality seen in acromegaly patients can be reversed with modern treatment aimed at normalizing GH and IGF-I levels. One year before death, the presented case was diagnosed with hypertension, but was otherwise described as healthy. The forensic autopsy, including post-mortem CT, showed phenotypic facial and body characteristics for acromegaly, general visceromegaly, and a pituitary tumor. The cause of death was heart failure due to end-stage acromegalic cardiopathy. Because the disease is slowly progressive, the individual himself, and the people close to him, might not have considered the acromegaly-related facial changes as abnormal.

Indexed as

AcromegalyHeart FailureHuman Growth HormoneAdultDeath, SuddenHumansMaleHuman Growth HormoneAcral enlargementAcromegalic cardiomyopathyAcromegalyPituitary tumorSudden death

Identifiers

PMID33847875
OpenAlexW3154734705

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.